Organization | Bill and Melinda Gates Foundation

Bill and Melinda Gates Foundation Report issue

Foundation Phase 1 Phase 2 Phase 3 Phase 4

Founded: Seattle WA United States (2000)

Organization Overview

First Clinical Trial

2000

NCT00198718

First Marketed Drug

None

First NDA Approval

None

Last Known Activity

2023

Timeline

NOW

Now

Alternative names

Alopecia Areata Initiative - Gates Foundation | Bill and Melinda Gates Foundation | Bill and Melinda Gates Medical Research Institute | Bill & Melinda Gates Medical Research Institute | Gates Foundation | Gates Malaria Partnership

Active Ingredients

Drugs in Phase 4 Trials (31)

10-valent Pneumococcal Conjugate Vaccine (Pneumosil) (1 trial)

albendazole (Albenza) (4 trials)

azithromycin (zithromax) (21 trials)

bivalent oral polio vaccine (bopv), type 1 and type 3 (BOPV) (7 trials)

emtricitabine (emtriva) (5 trials)

ethambutol (myambutol) (5 trials)

folic acid (6 trials)

inactivated influenza vaccine (7 trials)

Inactivated polio virus - Enhanced (IPOL) (13 trials)

iron (4 trials)

isoniazid (nydrazid) (7 trials)

labetalol (trandate) (1 trial)

live oral poliovirus type 1, 2 and 3 (Trivalent oral polio vaccine - Sabin) (4 trials)

medroxyprogesterone (provera) (3 trials)

menafrivac (1 trial)

Meningococcal (Groups A, C, Y, W) Conjugate Vaccine (MenQuadfi) (1 trial)

methyldopa (aldomet) (2 trials)

monovalent oral polio vaccines (mopv2) (MOPV2) (5 trials)

nifedipine (procardia) (1 trial)

novel opv2 (3 trials)

ondansetron (zofran) (2 trials)

pneumococcal 13-valent conjugate vaccine (prevnar 13) (2 trials)

polio, inactivated poliovirus vaccine (Salk Vaccine) (4 trials)

progestin (3 trials)

pyrazinamide (Aldinamide) (5 trials)

pyrimethamine (daraprim) (7 trials)

rifampin (5 trials)

sulfadoxine (7 trials)

tenofovir (viread) (11 trials)

tranexamic acid (cyklokapron) (2 trials)

vi-dt typhoid conjugate vaccine (2 trials)

Drugs in Phase 3 Trials (60)

aciclovir (zovirax) (1 trial)

alvac-hiv vaccine (2 trials)

amodiaquine (camoquin) (4 trials)

artemether (1 trial)

artesunate (6 trials)

as01 (2 trials)

bifidobacterium infantis (1 trial)

bivalent subtype c gp120 (2 trials)

cabotegravir (Vocabria) (1 trial)

carrageenan (4 trials)

cellulose (1 trial)

chadox1 (3 trials)

chlorhexidine (hibitane) (3 trials)

chloroquine (3 trials)

clarithromycin (biaxin) (1 trial)

coartem (2 trials)

COVID-19 convalescent plasma (1 trial)

desflurane (suprane) (2 trials)

dihydroartemisinin (5 trials)

ferric sulfate (1 trial)

human papillomavirus 9-valent vaccine, recombinant (Gardasil 9) (1 trial)

human papillomavirus quadrivalent (types 6, 11, 16 and 18) vaccine, recombinant (Gardasil) (1 trial)

human rotavirus, live attenuated (Rotarix) (2 trials)

hydroxychloroquine (plaquenil) (4 trials)

inactivated poliovirus type 2 vaccine (3 trials)

lamivudine (epivir) (1 trial)

lansoprazole (prevacid) (1 trial)

live attenuated influenza virus vaccine (Flumist) (1 trial)

lopinavir (Kaletra) (1 trial)

lumefantrine (Coartem) (3 trials)

mebendazole (vermox) (1 trial)

metronidazole (flagyl) (2 trials)

Molnupiravir (1 trial)

Monovalent group A meningococcal vaccine (Menomune-A) (1 trial)

multivitamins (1 trial)

naltrexone (revia) (1 trial)

nicotinamide (1 trial)

nitazoxanide (Alinia) (1 trial)

novel oral polio vaccine type 1 (nopv1) (2 trials)

novel oral polio vaccine type 2 (nopv2) (2 trials)

piperaquine (5 trials)

procaine benzylpenicillin (novocaine) (1 trial)

pyronaridine (1 trial)

ritonavir (Norvir) (1 trial)

rsv-f subunit vaccine (1 trial)

scb-2019 (3 trials)

stavudine (zerit) (1 trial)

tocilizumab (actemra) (1 trial)

tv p2-vp8 (1 trial)

typhoid vaccine (2 trials)

vitamin a (4 trials)

vitamin c (3 trials)

vitamin d3 (2 trials)

vitamin e (1 trial)

water (1 trial)

zinc (3 trials)

zinc dichloride (2 trials)

Drugs in Phase 2 Trials (45)

3bnc117 (1 trial)

abhayrab rabies vaccine (1 trial)

atorvastatin (lipitor) (1 trial)

bacille calmette-guerin (2 trials)

bedaquiline (sirturo) (2 trials)

bupropion (wellbutrin) (1 trial)

cetylpyridinium chloride (1 trial)

chadox1 n-cov vaccine (1 trial)

clofazimine (lamprene) (1 trial)

coronavac (1 trial)

delamanid (3 trials)

erlotinib (tarceva) (1 trial)

fp9 me-trap (1 trial)

hepatitis e vaccine (1 trial)

iowh032 (1 trial)

irbesartan (avapro) (1 trial)

killed oral cholera vaccine (3 trials)

lactobacillus plantarum (1 trial)

leish-111f + mpl-se (5 trials)

matrix m1 (1 trial)

methylene blue (proveblue) (1 trial)

monovalent oral polio vaccines (mopv1) (MOPV1) (3 trials)

novel oral polio vaccine type 3 (nopv3) (2 trials)

opc-167832 (3 trials)

pafuramidine maleate (2 trials)

pentamidine (pentam) (1 trial)

pneumococcal protein vaccine (1 trial)

potassium alum (1 trial)

pretomanid (1 trial)

primaquine (4 trials)

rilpivirine (edurant) (1 trial)

rivaroxaban (xarelto) (1 trial)

ruxolitinib (jakafi) (1 trial)

rv3-bb (1 trial)

sars-cov-2 rs (1 trial)

SB257049 (1 trial)

sf2a-tt15 (1 trial)

sodium chloride (1 trial)

sunitinib (sutent) (1 trial)

sutezolid (1 trial)

trivalent p2-vp8 (1 trial)

vcp1521 (1 trial)

vivomixx (1 trial)

vrc-hivmab080-00-ab (1 trial)

vsl #3 (2 trials)

Drugs in Phase 1 Trials (35)

10e8.4/imab (1 trial)

aluminum hydroxide (Gaviscon) (1 trial)

attenuated measles vaccine - Edmonston strain (rubeovax) (1 trial)

betamethasone (celestone) (1 trial)

caf®10b (1 trial)

calcium (1 trial)

calcium carbonate (1 trial)

cn54env dna (1 trial)

dexamethasone (1 trial)

emodepside (3 trials)

etonogestrel (1 trial)

genevax il-12-4532 (1 trial)

gla-se (3 trials)

gramicidin (1 trial)

h107e (1 trial)

hiv glycoprotein cn54gp140 vaccine (1 trial)

ibalizumab-uiyk (trogarzo) (1 trial)

id93 (2 trials)

ihv01 (1 trial)

lactobacillus crispatus (1 trial)

lc106 (1 trial)

leish-f3 (1 trial)

leish-f3 + sla-se (1 trial)

mam01 (1 trial)

mk-7762 (1 trial)

na-asp-2 (1 trial)

neomycin (1 trial)

pbtz169 (2 trials)

petrolatum, white (Vaseline) (1 trial)

polyacrylamide (1 trial)

rsm01 (1 trial)

rubella virus vaccine live (Meruvax) (1 trial)

vax102 (1 trial)

vir-1111 (1 trial)

Drugs in Other Trials (20)

adipic acid (1 trial)

atovaquone (mepron) (2 trials)

chlorproguanil (1 trial)

cow milk (1 trial)

dapsone (aczone) (1 trial)

desogestrel (Mercilon) (1 trial)

ethinyl estradiol (Estinyl) (1 trial)

ferrous sulfate (1 trial)

iron-enriched koji (1 trial)

iron hydroxide adipate (1 trial)

lactobacillus (1 trial)

magnesium sulfate (Tis-U-Sol) (1 trial)

misoprostol (cytotec) (2 trials)

oxytocin (syntocinon) (2 trials)

proguanil (2 trials)

pyrequan (1 trial)

salmonella typhi vaccine (1 trial)

tartaric acid (1 trial)

thiamine (1 trial)

zhi byed (1 trial)

Indications

Experimental Indications (Clinical Trials, Phases 1-4)

Acquired Immunodeficiency Syndrome (Phase 4)

Alopecia (Phase 2)

Alopecia Areata (Phase 2)

Ancylostomiasis (Phase 1)

Anemia (Phase 3)

Birth Weight (Phase 4)

Campylobacter Infections (Phase 3)

Cardiac Complexes, Premature (Phase 3)

Cholera (Phase 2)

Cleft Lip (Phase 3)

Cleft Palate (Phase 3)

Communicable Diseases (Phase 4)

Coronavirus Infections (Phase 3)

Cryptosporidiosis (Phase 2)

Death (Phase 3)

Dehydration (Phase 4)

Diarrhea (Phase 4)

Dysentery, Bacillary (Phase 2)

Eclampsia (Phase 3)

Enterocolitis (Phase 3)

Enterocolitis, Necrotizing (Phase 3)

Filariasis (Phase 4)

Gastroenteritis (Phase 4)

Gonorrhea (Phase 2)

HELLP Syndrome (Phase 3)

Helminthiasis (Phase 4)

Hemorrhagic Fever, Ebola (Phase 2)

Herpes Genitalis (Phase 3)

Herpes Simplex (Phase 3)

HIV Infections (Phase 4)

HIV Seropositivity (Phase 3)

Hookworm Infections (Phase 1)

Hypertension (Phase 4)

Hypertension, Pregnancy-Induced (Phase 4)

Immunologic Deficiency Syndromes (Phase 4)

Infant Death (Phase 4)

Infant, Newborn, Diseases (Phase 3)

Infant Nutrition Disorders (Phase 4)

Infections (Phase 4)

Influenza, Human (Phase 4)

Intestinal Diseases (Phase 3)

Kwashiorkor (Phase 3)

Latent Tuberculosis (Phase 4)

Leishmaniasis (Phase 2)

Leishmaniasis, Cutaneous (Phase 2)

Leishmaniasis, Mucocutaneous (Phase 1)

Leishmaniasis, Visceral (Phase 1)

Malaria (Phase 4)

Malnutrition (Phase 4)

Maternal Death (Phase 3)

Measles (Phase 1)

Meningitis (Phase 4)

Mycobacterium Infections (Phase 2)

Neonatal Sepsis (Phase 3)

Night Blindness (Phase 3)

Papillomavirus Infections (Phase 3)

Perinatal Death (Phase 3)

Periodontitis (Phase 2)

Pneumococcal Infections (Phase 4)

Pneumonia (Phase 4)

Poliomyelitis (Phase 4)

Pre-Eclampsia (Phase 4)

Pregnancy Complications, Infectious (Phase 3)

Pregnancy, Ectopic (Phase 3)

Premature Birth (Phase 3)

Puerperal Infection (Phase 3)

Respiratory Syncytial Virus Infections (Phase 3)

Rotavirus Infections (Phase 3)

Rubella (Phase 1)

Sepsis (Phase 3)

Severe Acute Respiratory Syndrome (Phase 3)

Sexually Transmitted Diseases (Phase 3)

Sprue, Tropical (Phase 3)

Stillbirth (Phase 4)

Syndrome (Phase 3)

Syphilis (Phase 2)

Tinea Capitis (Phase 3)

Toxemia (Phase 3)

Trachoma (Phase 4)

Trichomonas Vaginitis (Phase 2)

Trypanosomiasis (Phase 2)

Trypanosomiasis, African (Phase 2)

Tuberculosis (Phase 4)

Tuberculosis, Pulmonary (Phase 4)

Typhoid Fever (Phase 3)

Vaginitis (Phase 2)

Virus Diseases (Phase 3)

Vitamin A Deficiency (Phase 3)

Vomiting (Phase 4)

Overview

Highest Phase: Phase 4
# of Trials: 221
# of Trial APIs: 191