Active Ingredient History
Stavudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Stavudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated. Stavudine inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Stavudine is used for the treatment of human immunovirus (HIV) infections. Stavudine is sold under the brand name Zerit among others. NCATS
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Acidosis, Lactic (Phase 2/Phase 3)
Acquired Immunodeficiency Syndrome (Phase 4)
AIDS-Associated Nephropathy (Phase 3)
AIDS Dementia Complex (Phase 3)
AIDS-Related Opportunistic Infections (Phase 4)
Cardiovascular Diseases (Phase 4)
Drugs, Investigational (Phase 4)
Hemophilia A (Phase 4)
Herpesvirus 8, Human (Phase 4)
HIV (Phase 4)
HIV-Associated Lipodystrophy Syndrome (Phase 4)
HIV Seropositivity (Phase 2)
Lipodystrophy (Phase 4)
Liver Diseases (Phase 4)
Metabolic Diseases (Phase 4)
Pregnancy (Phase 1)
Sarcoma, Kaposi (Phase 4)
Tuberculosis (Phase 1)
Trial | Phase | Start Date | Organizations | Indications |
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