Active Ingredient History

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Cholecalciferol (/ˌkoʊləkælˈsɪfərɒl/) (vitamin D3) is one of the five forms of vitamin D. Cholecalciferol is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, in mineralization of bone, and for the assimilation of Vitamin A. The classical manifestation of vitamin D deficiency is rickets, which is seen in children and results in bony deformities including bowed long bones. Most people meet at least some of their vitamin D needs through exposure to sunlight. Ultraviolet (UV) B radiation with a wavelength of 290–320 nanometers penetrates uncovered skin and converts cutaneous 7-dehydrocholesterol to previtamin D3, which in turn becomes vitamin D3. In supplements and fortified foods, vitamin D is available in two forms, D2 (ergocalciferol) and D3 (cholecalciferol) that differ chemically only in their side-chain structure. Vitamin D2 is manufactured by the UV irradiation of ergosterol in yeast, and vitamin D3 is manufactured by the irradiation of 7-dehydrocholesterol from lanolin and the chemical conversion of cholesterol. The two forms have traditionally been regarded as equivalent based on their ability to cure rickets and, indeed, most steps involved in the metabolism and actions of vitamin D2 and vitamin D3 are identical. Both forms (as well as vitamin D in foods and from cutaneous synthesis) effectively raise serum 25(OH) D levels. Firm conclusions about any different effects of these two forms of vitamin D cannot be drawn. However, it appears that at nutritional doses, vitamins D2 and D3 are equivalent, but at high doses, vitamin D2 is less potent. The American Academy of Pediatrics (AAP) recommends that exclusively and partially breastfed infants receive supplements of 400 IU/day of vitamin D shortly after birth and continue to receive these supplements until they are weaned and consume ≥1,000 mL/day of vitamin D-fortified formula or whole milk. Cholecalciferol is used in diet supplementary to treat Vitamin D Deficiency. Cholecalciferol is inactive: it is converted to its active form by two hydroxylations: the first in the liver, the second in the kidney, to form calcitriol, whose action is mediated by the vitamin D receptor, a nuclear receptor which regulates the synthesis of hundreds of enzymes and is present in virtually every cell in the body. Calcitriol increases the serum calcium concentrations by increasing GI absorption of phosphorus and calcium, increasing osteoclastic resorption, and increasing distal renal tubular reabsorption of calcium. Calcitriol appears to promote intestinal absorption of calcium through binding to the vitamin D receptor in the mucosal cytoplasm of the intestine. Subsequently, calcium is absorbed through formation of a calcium-binding protein.   NCATS

  • SMILES: CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@]1(C)CCC\C2=C/C=C3/C[C@H](O)CCC3=C
  • InChIKey: QYSXJUFSXHHAJI-YHJXBONMSA-N
  • Mol. Mass: 384.6377
  • ALogP: 7.62
  • ChEMBL Molecules:
More Chemistry
  • Mechanisms of Action: Missing data
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral, Parenteral
  • Pro Drug: No

Combination drugs

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( vitamin d3, vitamin e, dexpanthenol (Berocca), folic acid, cyanocobalamin (berocca), vitamin c, nicotinamide, thiamine, vitamin k, biotin, pyridoxine, riboflavin, vitamin a - other names: infuvite pediatric, infuvite pediatric (pharmacy bulk package) )
(1s,3z)-3-[(2e)-2-[(1r,3ar,7as)-7a-methyl-1-[(2r)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol | (1s,3z)-3-[(2e)-2-[(1r,3as,7ar)-7a-methyl-1-[(2r)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol | (3β,5z,7e)-9,10-secocholesta-5,7,10(19)-trien-3-ol | (5z,7e)-(3s)-9,10-secocholesta-5,7,10(19)-trien-3-ol | accrete d3 | aciferol d3 | activated 7-dehydrocholesterol | adcal-d3 | alendronate sodium trihydrate / colecalciferol | alendronic acid / colecalciferol | arachitol | aviticol | biolife vitamin d3 | bio-vitamin d3 | cacit d3 | calceos | calcichew d3 | calcichew d3 fte | calcichew d3 once daily | calci-d | calciol | calcirol | caldrink d3 | calfovit d3 | cc | cholecalciferol | colcalciferol | colecalciferol | colecalciferolum | colecal d3 | colekal-d3 | colevit d3 | cubicole d3 | d3-50 | d3 lemon melts | dekristol | desunin | dlux 400 | d-max | dp-r206 | d-tracetten | d-vit3 | e-d3 | evacal d3 | fultium-d3 | fultium daily d3 | high dose aspirin & vitamin d | hux d3 | invita d3 | iso d3 | kora liquid | natecal d3 | nature's remedy vitamin d3 | neo-d | nphd3 | oleovitamin d3 | osteocaps d3 | plenachol | pro d3 | pro d3 folic | pro d3 forte | provitamin d(3) | royalvit d3 | stexerol-d3 | stivit-d3 | sunvit-d3 1,000 | sunvit-d3 10,000 | sunvit-d3 2,000 | sunvit-d3 20,000 | sunvit-d3 3,000 | sunvit-d3 400 | sunvit-d3 5,000 | sunvit-d3 50,000 | sunvit-d3 800 | synervit-d3 | theical d-3 | thorens | vigantol | vigantoletten | vigantoletten 500 | vigantol oil | viosterol | viosterol in oil | vita-d3 | vitamin d | vitamin-d | (+)-vitamin d3 | vitamin d3 | vitamin d 3 | vitamin d-3 | vitamin d nos | vitamin d, unspecified form | vit d3 streuli | zymad

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