Active Ingredient History
Ethinyl estradiol is a synthetic derivative of the natural estrogen estradiol. It is one of two estrogens currently used in oral contraceptive pills. The other, mestranol, is converted to ethinyl estradiol before it is biologically active. Ethinyl estradiol and norethindrone are used together as an oral contraceptive agent. Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. This cascade is initiated by initially binding to the estrogen receptors. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH). Used for treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive. NCATS
Combination drugs
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Pregnancy (approved 2002)
Acromegaly (Phase 2)
Adenomyosis (Phase 2)
Affect (Phase 4)
Amenorrhea (Phase 4)
Anemia, Aplastic (Phase 1/Phase 2)
Anorexia Nervosa (Phase 2/Phase 3)
Arthritis (Phase 1)
Arthritis, Psoriatic (Phase 1)
Arthritis, Rheumatoid (Phase 3)
Bacterial Infections (Phase 1)
Bariatric Surgery (Phase 4)
Binge-Eating Disorder (Phase 2)
Biological Availability (Phase 1)
Bipolar Disorder (Phase 2)
Blood Pressure (Phase 4)
Body Weight (Phase 4)
Bone Diseases, Metabolic (Phase 3)
Bulimia (Phase 2)
Bulimia Nervosa (Phase 2)
Carcinoma, Non-Small-Cell Lung (Phase 1)
Cardiovascular Diseases (Phase 4)
Chlamydia Infections (Phase 4)
Chronic Pain (Phase 4)
Contraception (Phase 4)
Contraception Behavior (Phase 4)
Contraception, Postcoital (Phase 4)
Contraceptive Agents (Phase 4)
Contraceptives, Oral (Phase 3)
Contraceptives, Oral, Combined (Phase 4)
Cystic Fibrosis (Phase 1)
Cystitis, Interstitial (Phase 4)
Depression (Phase 4)
Depressive Disorder, Major (Phase 1)
Diabetes Mellitus (Phase 1)
Diabetes Mellitus, Type 2 (Phase 1)
Drug Interactions (Phase 1)
Drugs, Investigational (Phase 1)
Dysmenorrhea (Phase 4)
Dyspareunia (Phase 4)
Embryo Transfer (Phase 1)
Endometrial Neoplasms (Phase 2)
Endometriosis (Phase 4)
Epilepsies, Partial (Phase 1)
Epilepsy (Phase 1)
Estradiol (Phase 1)
Exercise (Phase 3)
Fallopian Tube Diseases (Early Phase 1)
Feeding and Eating Disorders (Phase 2)
Female (Phase 1)
Fertility (Phase 4)
General Surgery (Early Phase 1)
Growth and Development (Phase 4)
Guillain-Barre Syndrome (Phase 3)
Headache (Phase 3)
Health (Phase 4)
Healthy Volunteers (Phase 4)
Heart Disease Risk Factors (Phase 4)
Hematologic Neoplasms (Phase 1)
Hemostasis (Phase 2)
Hepacivirus (Phase 1)
Hepatitis B, Chronic (Phase 1)
Hepatitis C (Phase 1)
Hepatitis C, Chronic (Phase 1)
Hidradenitis Suppurativa (Phase 2)
HIV (Phase 4)
HIV Infections (Phase 4)
Hyperandrogenism (Phase 4)
Hypertension (Phase 2)
Infertility (Phase 4)
Infertility, Female (Phase 3)
Inflammatory Bowel Diseases (Phase 1)
Insulin Resistance (Phase 4)
Joint Diseases (Phase 4)
Leiomyoma (Phase 3)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 1)
Libido (Phase 3)
Ligaments (Phase 4)
Light (Phase 4)
Live Birth (Phase 4)
Lupus Erythematosus, Systemic (Phase 3)
Medicine, Chinese Traditional (Phase 4)
Menopause (Phase 4)
Menorrhagia (Phase 4)
Menstruation (Phase 3)
Menstruation Disturbances (Phase 4)
Metabolic Syndrome (Phase 4)
Metabolism (Phase 1/Phase 2)
Metrorrhagia (Phase 2)
Migraine Disorders (Phase 4)
Multiple Sclerosis (Phase 1)
Neisseriaceae Infections (Phase 4)
Neonatal Sepsis (Phase 3)
Neoplasms ()
Nervous System Malformations (Phase 3)
Neural Analyzers (Phase 4)
Neural Tube Defects (Phase 3)
Non-alcoholic Fatty Liver Disease (Phase 1)
Obesity (Phase 4)
Osteoporosis (Phase 2)
Ovarian Diseases (Phase 4)
Ovarian Follicle (Phase 1)
Ovarian Neoplasms (Early Phase 1)
Ovulation (Phase 3)
Ovulation Induction (Phase 1/Phase 2)
Ovulation Inhibition (Phase 3)
Pelvic Pain (Phase 4)
Pharmacokinetics (Phase 1)
Polycystic Ovary Syndrome (Phase 4)
Postmenopause (Phase 2)
Pregnancy (Phase 2)
Pregnancy Complications (Phase 4)
Pregnancy, Unplanned (Phase 2)
Prehypertension (Phase 2)
Premenstrual Dysphoric Disorder (Phase 4)
Premenstrual Syndrome (Phase 4)
Primary Ovarian Insufficiency (Phase 4)
Psoriasis (Phase 1)
Quality of Life (Phase 4)
Scleroderma, Systemic (Phase 1)
Sexual Health (Phase 4)
Therapeutic Equivalency (Phase 1)
Thrombophilia (Phase 4)
Turner Syndrome (Phase 3)
Uterine Diseases (Phase 4)
Uterine Hemorrhage (Phase 2)
Vaginal Diseases (Phase 3)
Vaginosis, Bacterial (Phase 4)
Visceral Pain (Phase 4)
Women (Phase 1)
Trial | Phase | Start Date | Organizations | Indications |
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