Active Ingredient History
Chlorhexidine is a broad-spectrum biocide effective against Gram-positive bacteria, Gram-negative bacteria and fungi. It is used primarily as its salts (e.g., the dihydrochloride, diacetate, and digluconate). Chlorhexidine inactivates microorganisms with a broader spectrum than other antimicrobials (e.g. antibiotics) and has a quicker kill rate than other antimicrobials (e.g. povidone-iodine). It has both bacteriostatic (inhibits bacterial growth) and bactericidal (kills bacteria) mechanisms of action, depending on its concentration. Chlorhexidine kills by disrupting the cell membrane. The most common side effects associated with chlorhexidine gluconate oral rinses are: 1) an increase in staining of teeth and other oral surfaces; 2) an increase in calculus formation; and 3) an alteration in taste perception; 4) toothache; 5) upper respiratory tract infection; and 6) headache. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Gingivitis (approved 1976)
Abscess (Phase 4)
Acanthamoeba Keratitis (Phase 3)
Acne Vulgaris (Phase 3)
Aggressive Periodontitis (Phase 4)
Allergy and Immunology (Phase 1)
Alveolar Bone Loss (Phase 1/Phase 2)
Alveolitis, Extrinsic Allergic (Phase 4)
Amputation, Surgical (Phase 4)
Anaplasia (Phase 3)
Anesthesia (Phase 3)
Ankle (Phase 4)
Antisepsis (Phase 4)
Arrhythmias, Cardiac (Phase 4)
Arthroplasty (Phase 4)
Arthroplasty, Replacement, Hip (Phase 4)
Arthroplasty, Replacement, Knee (Phase 4)
Bacteremia (Phase 4)
Bacteria (Phase 4)
Bacterial Infections (Phase 4)
Bacteriuria (Phase 4)
Biofilms (Phase 4)
Blood Pressure (Phase 4)
Breast Neoplasms (Phase 4)
Burns (Phase 2)
Candidiasis, Vulvovaginal (Phase 2)
Carcinoma, Non-Small-Cell Lung (Phase 2)
Cardiovascular Diseases (Phase 4)
Cariostatic Agents (Phase 2/Phase 3)
Catheterization (Phase 2/Phase 3)
Catheter-Related Infections (Phase 4)
Catheters (Phase 4)
Cesarean Section (Phase 4)
Chemical Actions and Uses (Early Phase 1)
Chlorhexidine (Phase 4)
Chronic Periodontitis (Phase 3)
Clostridioides difficile (Phase 4)
Clostridium Infections (Phase 1)
Colonic Diseases (Phase 4)
Colonic Neoplasms (Phase 4)
Communicable Diseases (Phase 3)
Coronavirus Infections (Phase 2)
COVID-19 (Phase 4)
Cross Infection (Phase 4)
Cystic Fibrosis (Phase 2)
Deglutition Disorders (Phase 3)
Dental Caries (Phase 4)
Dental Implantation (Early Phase 1)
Dental Implants (Phase 4)
Dental Plaque (Phase 4)
Dental Pulp Necrosis (Phase 2)
Dentist-Patient Relations (Phase 1)
Dermatology (Phase 4)
Diabetes Mellitus (Phase 4)
Diabetes Mellitus, Type 2 (Phase 4)
Diabetic Angiopathies (Early Phase 1)
Diabetic Foot (Phase 4)
Disinfection (Early Phase 1)
Drug-Related Side Effects and Adverse Reactions (Phase 2/Phase 3)
Drugs, Investigational (Phase 4)
Dry Socket (Phase 4)
Endodontics (Phase 2/Phase 3)
Esophageal Neoplasms (Phase 2/Phase 3)
Exanthema (Phase 1)
Foot Dermatoses (Phase 4)
Fractures, Bone (Phase 4)
Frail Elderly (Phase 4)
Frailty (Phase 1/Phase 2)
Gastrointestinal Microbiome (Phase 4)
Gels (Phase 4)
General Surgery (Phase 4)
Gingival Diseases (Phase 4)
Gingival Recession (Phase 4)
Gingivitis (Phase 4)
Halitosis (Phase 2)
Hamartoma (Phase 4)
Hand Hygiene (Phase 4)
Hand Injuries (Phase 4)
Head and Neck Neoplasms (Phase 1)
Healthcare-Associated Pneumonia (Phase 4)
Healthy Volunteers (Phase 4)
Heart Diseases (Phase 1)
Heart Failure (Phase 4)
Heart Failure, Diastolic (Phase 1)
Hematopoietic Stem Cell Transplantation (Phase 2)
Hemorrhage (Phase 3)
Hemorrhoids (Phase 2)
HIV Infections (Phase 2)
Hypertension, Pulmonary (Phase 1)
Hypochlorous Acid (Phase 2)
Hysterectomy (Phase 4)
Immune System Diseases (Phase 1/Phase 2)
Infant Mortality (Phase 3)
Infant, Newborn, Diseases (Phase 3)
Infant, Premature (Phase 2)
Infections (Phase 4)
Inflammation (Phase 4)
Keratitis (Phase 3)
Kidney Failure, Chronic (Phase 4)
Laparotomy (Phase 3)
Leg Ulcer (Phase 4)
Leukemia, Myeloid (Phase 3)
Leukemia, Myeloid, Acute (Phase 3)
Liver Neoplasms (Phase 4)
Long Term Adverse Effects (Phase 1/Phase 2)
Lung Neoplasms (Phase 2/Phase 3)
Macular Degeneration (Early Phase 1)
Malocclusion (Phase 3)
Microbiota (Phase 4)
Molar, Third (Phase 4)
Mouth (Phase 4)
Mouth Diseases (Phase 3)
Mouthwashes (Phase 2/Phase 3)
Mucositis (Phase 4)
Myelodysplastic Syndromes (Phase 2/Phase 3)
Neonatal Sepsis (Phase 2/Phase 3)
Neonatology (Phase 2/Phase 3)
Neoplasms (Phase 3)
Neutropenia (Phase 3)
Nicotine (Phase 1)
Nursing Homes (Phase 4)
Obesity (Phase 4)
Obesity, Morbid (Phase 4)
Oral Health (Phase 4)
Oral Hygiene (Phase 4)
Oral Manifestations (Phase 2)
Oral Ulcer (Phase 4)
Oropharyngeal Neoplasms (Phase 2)
Osteoarthritis (Phase 2)
Osteonecrosis (Phase 4)
Pain (Phase 3)
Pancreatitis, Acute Necrotizing (Phase 4)
Pathologic Processes (Phase 3)
Penile Diseases (Phase 2)
Periapical Abscess (Phase 2/Phase 3)
Periapical Periodontitis (Phase 3)
Peri-Implantitis (Phase 4)
Periodontal Diseases (Phase 4)
Periodontal Index (Phase 3)
Periodontal Pocket (Phase 3)
Periodontitis (Phase 4)
Peritoneal Dialysis (Phase 4)
Personal Satisfaction (Phase 4)
Pharyngitis (Phase 4)
Pneumonia (Phase 4)
Pneumonia, Aspiration (Phase 4)
Pneumonia, Ventilator-Associated (Phase 4)
Postoperative Complications (Phase 3)
Postoperative Nausea and Vomiting (Phase 4)
Postpartum Period (Phase 1/Phase 2)
Pregnant Women (Phase 4)
Propionibacterium acnes (Phase 4)
Prostheses and Implants (Phase 1/Phase 2)
Prosthesis-Related Infections (Phase 3)
Pseudomonas aeruginosa (Phase 4)
Puerperal Infection (Phase 3)
Pulmonary Disease, Chronic Obstructive (Phase 2)
Pulpitis (Phase 3)
Radiodermatitis (Phase 2/Phase 3)
Respiratory Tract Infections (Phase 3)
Retinal Diseases (Early Phase 1)
Saliva (Phase 2/Phase 3)
Sepsis (Phase 4)
Skin Diseases, Infectious (Phase 4)
Spinal Injuries (Phase 4)
Staphylococcal Infections (Phase 1/Phase 2)
Staphylococcus aureus (Phase 4)
Stomatitis (Phase 4)
Stomatognathic Diseases (Early Phase 1)
Substance Abuse, Oral (Phase 4)
Surgery, Oral (Phase 4)
Surgical Wound Infection (Phase 4)
Sutures (Phase 4)
Toes (Phase 4)
Tooth Abnormalities (Phase 4)
Tooth Loss (Phase 3)
Tooth Socket (Phase 4)
Ultrasonography (Phase 4)
Umbilical Cord (Phase 3)
Urinary Tract Infections (Phase 4)
Vagina (Phase 4)
Ventilators, Mechanical (Phase 4)
Vitreoretinopathy, Proliferative (Early Phase 1)
Wound Healing (Phase 3)
Wound Infection (Phase 4)
Wounds and Injuries (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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