Herein, we summarize information about the clinical applications for all experimental and FDA-approved medicines. For these analyses, we adopt the Medical Subject Headings (MeSH) hierarchy as covered by the National Library of Medicine of the NIH. MeSH provides an accepted, albeit imperfect, way to convey ambiguities surrounding the many types of interventions included in CDEK, which include treatment, prevention and diagnosis of health and disease. Please note that the summaries below generally reflect the highest level of the MeSH hierarchies for Diseases (Group C), Psychiatry and Psychology (Group F) and Phenomena and Processes (Group G). For interventions that reflect multiple MeSH headings, we prioritize Groups C, F and G and in that order.
Experimental Indications
Top 20 (by most trials)
Approved Indications
Top 20 (by most approved APIs)
MeSH terms are hierarchical, starting with high-level subjects (e.g. Diseases [C]), and becoming increasingly specific as you traverse down the tree.
For example, acetylsalicylic acid (aspirin) is indicated for the treatment of Stroke, which is found in the MeSH Hierarchy at:
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Brain Diseases » Cerebrovascular Disorders » Stroke
Diseases [C] » Cardiovascular Diseases [C14] » Vascular Diseases » Cerebrovascular Disorders » Stroke
Alternatively, you can also browse indications via the ICD-10 Hierarchy (below), though note: this data is less complete.
