artesunate Report issue

Small molecule Orphan Drug FDA Approved FDA Fast Track FDA Breakthrough Therapy FDA Priority Review FDA
AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Artesunate (AS) is a medication used to treat malaria. The intravenous form is preferred to quinine for severe malaria. Often it is used as part of combination therapy, such as artesunate plus mefloquine. It is not used for the prevention of malaria. Artesunate can be given by injection into a vein, injection into a muscle, by mouth, and by rectum.   Wikipedia

Chemistry

  • SMILES: C[C@H]1[C@H](OC(=O)CCC(=O)O)O[C@@H]2O[C@@]3(C)CC[C@H]4[C@H](C)CC[C@@H]1[C@@]24OO3
  • InChIKey: FIHJKUPKCHIPAT-AHIGJZGOSA-N
  • Mol. Mass: 384.43
  • ALogP: 2.6
  • ChEMBL Molecule:
    artesunate  
More Chemistry

Pharmacology

  • Mechanisms of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Parenteral
  • Pro Drug: Yes

Alternative names

arinate | arsuamoon | arsumax | artesunate | artesunato | artesunatum | artesunic acid | as | butanedioic acid, 1-[(3r,5as,6r,8as,9r,10s,12r,12ar)-decahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester | cosunate | dihydroartemisinine-12-alpha-succinate | dihydroqinghasu hemsuccinate | malacef | malartin | sm 804 | sm-804 | sodium artesunate | succinyl dihydroartemisinin

Organizations (202)

Research & Development (201)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (45)

Approved Indications (1)


 

Malaria (approved 2020)

Experimental Indications - Clinical Trial Phases 1-4 (45)


 

Anemia (Phase 4)

Anemia, Sickle Cell (Phase 1/Phase 2)

Antimalarials (Phase 3)

Anus Neoplasms (Phase 2)

Artesunate (Phase 1)

Breast Neoplasms (Phase 1)

Carcinoma (Phase 2)

Carcinoma, Hepatocellular (Phase 1)

Carcinoma, Squamous Cell (Phase 2)

Cervical Intraepithelial Neoplasia (Phase 2)

Child (Phase 4)

Colorectal Neoplasms (Phase 2)

Coronavirus Infections (Phase 2)

COVID-19 (Phase 4)

Crohn Disease (Phase 2)

Cytomegalovirus Infections (Phase 3)

Fever (Phase 3)

Friedreich Ataxia (Phase 1/Phase 2)

Healthy Volunteers (Phase 4)

HIV (Phase 1)

Idiopathic Pulmonary Fibrosis (Phase 1)

Lupus Nephritis (Phase 4)

Malaria (Phase 4)

Malaria, Cerebral (Phase 1)

Malaria, Falciparum (Phase 4)

Malaria, Vivax (Phase 4)

Malnutrition (Phase 4)

Neoplasms (Phase 2)

Papillomaviridae (Phase 1)

Papillomavirus Infections (Phase 2)

Parasitemia (Phase 3)

Parasitic Diseases (Phase 4)

Plasmodium falciparum (Phase 3)

Precancerous Conditions (Phase 2)

Precursor Cell Lymphoblastic Leukemia-Lymphoma (Phase 4)

Pregnancy (Phase 3)

Pregnancy Complications (Phase 3)

Schistosoma haematobium (Phase 3)

Schistosoma mansoni (Phase 3)

Schistosomiasis haematobia (Phase 2)

Sprains and Strains (Phase 1)

Uterine Cervical Dysplasia (Phase 2)

Uterine Cervical Neoplasms (Phase 1)

Vulvar Diseases (Phase 1)

Vulvar Neoplasms (Phase 1)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 202
  • # of Trial Organizations: 201

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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