Related MeSH Hierarchy (6)
Diseases [C] » Infections [C01] » Virus Diseases » RNA Virus Infections » Picornaviridae Infections » Enterovirus Infections » Poliomyelitis
Diseases [C] » Nervous System Diseases [C10] » Neuroinflammatory Diseases » Myelitis » Poliomyelitis
Diseases [C] » Infections [C01] » Central Nervous System Infections » Myelitis » Poliomyelitis
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Central Nervous System Infections » Myelitis » Poliomyelitis
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Spinal Cord Diseases » Myelitis » Poliomyelitis
Diseases [C] » Nervous System Diseases [C10] » Neuromuscular Diseases » Poliomyelitis
Description
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5) MeSH
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Subtype Terms (2)
Postpoliomyelitis Syndrome
8 drugs (6 approved, 2 experimental)
Approved Indicated Drugs (14)
anti-poliomyelitis serum (Polio Antisera (equine))
bivalent oral polio vaccine (bopv), type 1 and type 3 (BOPV)
DTaP, inactivated poliovirus, haemophilus influenzae b conjugate, hepatitis b vaccine (Pediarix)
Inactivated polio virus - Enhanced (IPOL)
inactivated poliovirus type 2 vaccine
inactivated sabin strain polio virus
live oral poliovirus type 1, 2 and 3 (Trivalent oral polio vaccine - Sabin)
Phase 3 Indicated Drugs (20)
10-valent Pneumococcal Conjugate Vaccine (Pneumosil)
acellular pertussis vaccine (ACEL-IMUNE\T)
glyco-conjugate neisseria meningitidis serogroup c vaccine
human papillomavirus quadrivalent (types 6, 11, 16 and 18) vaccine, recombinant (Gardasil)
Other Experimental Indicated Drugs (3)
Organization Involved with Phase 4 Indications (28)
Bill and Melinda Gates Foundation
Centers for Disease Control and Prevention (CDC)
Centers for Disease Control and Prevention, China
Organization Involved with Phase 3 Indications (26)
Organization Involved with Phase 2 Indications (8)
Organization Involved with Phase 1 Indications (10)
Organization Involved with Other Experimental Indications (5)
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UMLS Data
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