Active Ingredient History
Azithromycin is one of the world's best-selling antibiotics, used to treat or prevent certain bacterial infections: Acute bacterial exacerbations of chronic bronchitis in adults; acute bacterial sinusitis in adults; uncomplicated skin and skin structure infections in adults; urethritis and cervicitis in adults; genital ulcer disease in men; acute otitis media in pediatric patients; community-acquired pneumonia in adults and pediatric patients; pharyngitis/tonsillitis in adults and pediatric patients. Azithromycin should not be used in patients with pneumonia who are judged inappropriate for oral therapy because of moderate to severe illness or risk factors. A team of researchers at the Croatian pharmaceutical company Pliva, discovered azithromycin in 1980. It was patented in 1981. In 1986, Pliva and Pfizer signed a licensing agreement, which gave Pfizer exclusive rights for the sale of azithromycin in Western Europe and the United States. Pliva put its azithromycin on the market in Central and Eastern Europe under the brand name of Sumamed in 1988. Pfizer launched azithromycin under Pliva's license in other markets under the brand name Zithromax in 1991. Azithromycin is a semi-synthetic macrolide antibiotic of the azalide class. Like other macrolide antibiotics, azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of the bacterial 70S ribosome. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the process of translation. Its effects may be bacteriostatic or bactericidal depending of the organism and the drug concentration. Its long half-life, which enables once daily dosing and shorter administration durations, is a property distinct from other macrolides. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Bronchitis, Chronic (approved 1991)
Otitis Media (approved 1991)
Sinusitis (approved 1991)
Staphylococcal Skin Infections (approved 1991)
Abdominal Pain (Phase 3)
Acne Vulgaris (Phase 3)
Acute Chest Syndrome (Phase 1)
Adenomatous Polyposis Coli (Phase 4)
Alveolar Bone Loss (Phase 4)
Ambulatory Care (Phase 3)
Anemia (Phase 3)
Anemia, Sickle Cell (Phase 1/Phase 2)
Anti-Bacterial Agents (Phase 4)
Arthritis, Reactive (Phase 3)
Asthma (Phase 4)
Autoimmune Diseases (Phase 1)
Azithromycin (Phase 4)
Bacterial Infections (Phase 4)
Bartonella Infections (Phase 4)
Biological Availability (Phase 1)
Blepharitis (Phase 4)
Bronchial Diseases (Phase 4)
Bronchiectasis (Phase 4)
Bronchiolitis (Phase 4)
Bronchiolitis Obliterans (Phase 4)
Bronchitis (Phase 3)
Bronchitis, Chronic (Phase 4)
Bronchopulmonary Dysplasia (Phase 4)
Campylobacter Infections (Phase 2/Phase 3)
Cardiovascular Diseases (Phase 3)
Cataract Extraction (Phase 4)
Cat-Scratch Disease (Phase 4)
Cefazolin (Phase 4)
Cerebral Intraventricular Hemorrhage (Phase 4)
Cesarean Section (Phase 2)
Child Development (Phase 4)
Child Health (Phase 4)
Child Mortality (Phase 4)
Child Nutrition Disorders (Phase 4)
Chlamydia (Phase 4)
Chlamydia trachomatis (Phase 4)
Cholera (Phase 3)
Chronic Periodontitis (Phase 4)
Cognition Disorders (Phase 2/Phase 3)
Coinfection (Phase 4)
Communicable Diseases (Phase 4)
Community-Acquired Infections (Phase 4)
Conjunctivitis (Phase 3)
Conjunctivitis, Bacterial (Phase 3)
Coronary Disease (Phase 3)
Coronavirus (Phase 3)
Coronavirus Infections (Phase 3)
Cough (Phase 3)
COVID-19 (Phase 4)
Crohn Disease (Phase 4)
Cryptogenic Organizing Pneumonia (Phase 2)
Cyclosteroids (Phase 4)
Death (Phase 4)
Delivery, Obstetric (Phase 4)
Dental Implantation (Phase 1)
Depression (Phase 4)
Diabetes Mellitus (Phase 2)
Diabetes Mellitus, Type 1 (Phase 2)
Diarrhea (Phase 4)
Diet Therapy (Phase 2)
Drug Resistance, Bacterial (Phase 4)
Dry Eye Syndromes (Phase 4)
Dysentery, Bacillary (Phase 4)
Dyspepsia (Phase 4)
Elephantiasis, Filarial (Phase 4)
Endocrine System Diseases (Phase 2)
Endometritis (Phase 4)
Enterocolitis, Necrotizing (Phase 4)
Esophageal Motility Disorders (Phase 2)
Exercise (Early Phase 1)
Eye Infections (Phase 4)
Eye Infections, Bacterial (Phase 1)
Eye Pain (Phase 4)
Fasting (Phase 1)
Fatty Liver (Phase 2)
Fetal Membranes, Premature Rupture (Phase 4)
Fever (Phase 4)
Fibrosis (Phase 4)
Gastritis (Phase 3)
Gastrointestinal Microbiome (Phase 4)
Gastroparesis (Phase 2)
Glucose Metabolism Disorders (Phase 2)
Gonorrhea (Phase 4)
Graft Rejection (Phase 4)
Graft vs Host Disease (Phase 2)
Graves Ophthalmopathy (Phase 1/Phase 2)
Growth and Development (Phase 4)
Growth Disorders (Phase 2/Phase 3)
Healthy Volunteers (Phase 4)
Heart Diseases (Phase 3)
Helicobacter pylori (Phase 4)
Helminthiasis (Phase 4)
Hematologic Neoplasms (Phase 2)
Hematopoietic Stem Cell Transplantation (Phase 1/Phase 2)
Hemorrhagic Fever, Ebola (Phase 1/Phase 2)
HIV (Phase 4)
HIV Infections (Phase 3)
Hospitalization (Phase 3)
Immune System Diseases (Phase 4)
Impetigo (Phase 4)
Infant, Premature (Phase 4)
Infections (Phase 4)
Inflammation (Phase 3)
Influenza, Human (Phase 4)
Insulin Resistance (Phase 2)
Intestinal Diseases (Phase 2/Phase 3)
Intestinal Neoplasms (Phase 2)
Intubation (Phase 1/Phase 2)
Keratitis (Phase 3)
Labor, Obstetric (Early Phase 1)
Leishmaniasis, Cutaneous (Phase 2/Phase 3)
Live Birth (Phase 4)
Liver Diseases (Phase 2)
Lung Diseases (Phase 4)
Lung Diseases, Interstitial (Phase 2)
Lung Diseases, Obstructive (Phase 4)
Lung Transplantation (Phase 4)
Lyme Disease (Phase 1/Phase 2)
Malaria (Phase 4)
Malaria, Falciparum (Phase 3)
Malnutrition (Phase 4)
Maternal Death (Phase 3)
Maxillary Sinusitis (Phase 4)
Meconium (Phase 4)
Meibomian Gland Dysfunction (Phase 4)
Metabolic Diseases (Phase 2)
Morals (Phase 4)
Mortality (Phase 4)
Multiple Sclerosis (Phase 2)
Mycobacterium avium Complex (Phase 4)
Mycobacterium Infections, Nontuberculous (Phase 4)
Mycoplasma (Phase 4)
Mycoses (Phase 3)
Myocardial Infarction (Phase 3)
Neisseria gonorrhoeae (Phase 4)
Neonatal Sepsis (Phase 3)
Neonatology (Phase 3)
Neoplasm Metastasis (Phase 3)
Neuropsychiatry (Phase 2)
Non-alcoholic Fatty Liver Disease (Phase 2)
Obesity (Early Phase 1)
Obsessive Behavior (Phase 2)
Obstetric Labor Complications (Phase 4)
Obstetric Labor, Premature (Phase 4)
Onchocerciasis (Phase 2)
Only Child (Phase 4)
Otitis Media (Phase 4)
Otitis Media, Suppurative (Phase 3)
Parasitic Diseases (Phase 3)
Pediatrics (Phase 4)
Pelvic Inflammatory Disease (Phase 4)
Peptic Ulcer (Phase 4)
Perinatal Death (Phase 4)
Periodontal Diseases (Phase 4)
Periodontitis (Phase 4)
Pharmacokinetics (Phase 4)
Pharyngitis (Phase 3)
Physiological Effects of Drugs (Phase 4)
Physiology (Phase 1)
Plasmodium (Phase 4)
Pleural Diseases (Phase 4)
Pneumonia ()
Pneumonia, Bacterial (Phase 4)
Pneumonia, Pneumocystis (Phase 2)
Pneumonia, Ventilator-Associated (Phase 2)
Pneumonia, Viral (Phase 3)
Postpartum Period (Phase 4)
Prebiotics (Phase 1)
Pre-Eclampsia (Phase 4)
Pregnancy (Phase 4)
Pregnancy Complications (Phase 4)
Premature Birth (Phase 4)
Probiotics (Phase 1)
Pseudomonas Infections (Phase 2)
Puerperal Infection (Phase 4)
Pulmonary Disease, Chronic Obstructive (Phase 4)
Quorum Sensing (Phase 1)
Respiratory Distress Syndrome (Phase 2)
Respiratory Insufficiency (Phase 3)
Respiratory Sounds (Phase 3)
Respiratory Syncytial Viruses (Early Phase 1)
Respiratory Syncytial Virus Infections (Phase 3)
Respiratory Tract Infections (Phase 4)
Sarcoidosis (Phase 2)
Sarcoidosis, Pulmonary (Phase 2)
SARS-CoV-2 (Phase 3)
Scabies (Phase 4)
Scrub Typhus (Phase 4)
Sepsis (Phase 4)
Severe Acute Malnutrition (Phase 4)
Severe Acute Respiratory Syndrome (Phase 3)
Sexually Transmitted Diseases (Phase 4)
Sinusitis (Phase 4)
Streptococcus (Phase 2)
Strongyloidiasis (Phase 3)
Syphilis (Phase 3)
Systemic Inflammatory Response Syndrome (Phase 2)
Therapeutic Equivalency (Phase 1)
Therapeutics (Phase 2/Phase 3)
Tonsillitis ()
Toxoplasmosis, Cerebral (Phase 1)
Tracheostomy (Phase 2)
Trachoma (Phase 4)
Treatment Adherence and Compliance (Phase 4)
Treatment Outcome (Phase 4)
Treponema (Phase 3)
Trichiasis (Phase 4)
Tropical Medicine (Phase 3)
Tuberculosis (Phase 3)
Tuberculosis, Pulmonary (Phase 2)
Typhoid Fever (Phase 4)
Ulcer (Phase 3)
Ureaplasma (Phase 1)
Ureaplasma Infections (Phase 2)
Urethritis ()
Urinary Bladder, Overactive (Phase 4)
Urinary Tract Infections (Phase 4)
Uterine Cervical Incompetence (Phase 4)
Uterine Cervicitis (Phase 4)
Vaginal Diseases (Phase 4)
Vaginosis, Bacterial (Phase 4)
Virus Diseases (Phase 2)
Vomiting (Phase 3)
Whooping Cough (Phase 2)
Wound Infection (Phase 2)
Wounds and Injuries (Phase 2)
Yaws (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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