Active Ingredient History
Nifedipine has been formulated as both a long- and short-acting 1,4-dihydropyridine calcium channel blocker. Nifedipine is sold under the brand names Adalat and Procardia among others. Nifedipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. The vasodilatory effects of nifedipine result in an overall decrease in blood pressure. Nifedipine is used for the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud's phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents). NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Adrenal Hyperplasia, Congenital (Phase 1/Phase 2)
Aging (Phase 2)
Altitude Sickness (Phase 4)
Anterior Cruciate Ligament Injuries (Phase 4)
Arthroscopy (Phase 4)
Atrial Fibrillation (Phase 4)
Bacterial Infections (Phase 4)
Blood Loss, Surgical (Phase 4)
Blood Pressure (Phase 4)
Cardiovascular Diseases (Phase 3)
Cerebral Palsy (Phase 2/Phase 3)
Cognitive Dysfunction (Phase 2)
Coronary Artery Disease (Phase 4)
Coronary Disease (Phase 3)
Cytochrome P-450 Enzyme System (Phase 1)
Delivery, Obstetric (Phase 3)
Dermatomyositis (Early Phase 1)
Diabetes Mellitus (Phase 4)
Diabetic Nephropathies (Phase 3)
Eczema (Phase 2)
Embryo Implantation (Phase 2)
Epilepsies, Partial (Phase 2)
Epilepsy (Phase 2)
Essential Hypertension (Phase 4)
Fissure in Ano (Phase 2/Phase 3)
Glioblastoma (Phase 1/Phase 2)
Healthy Volunteers (Phase 4)
Heart Diseases (Phase 3)
Hemochromatosis (Phase 1)
Hemorrhage (Phase 2/Phase 3)
Hypertension ()
Hypertension, Pregnancy-Induced (Phase 4)
Hypertension, Pulmonary (Phase 3)
Infant, Premature (Phase 3)
Iron Overload (Phase 1)
Kidney Calculi (Phase 3)
Kidney Failure, Chronic (Phase 4)
Labor, Obstetric (Phase 4)
Lung Diseases (Phase 2)
Lupus Erythematosus, Systemic (Early Phase 1)
Myocardial Ischemia (Phase 3)
Obesity, Morbid (Early Phase 1)
Obstetric Labor, Premature (Phase 4)
Opioid-Related Disorders (Phase 1)
Pharmacology (Phase 1)
Pharmacology, Clinical (Phase 1)
Placenta Previa (Phase 3)
Postoperative Hemorrhage (Phase 4)
Pre-Eclampsia (Phase 4)
Pregnancy Complications (Phase 3)
Premature Birth (Phase 4)
Proteinuria (Phase 2)
Psoriasis (Phase 2)
Raynaud Disease (Phase 3)
Rectal Diseases (Phase 2/Phase 3)
Renal Dialysis (Phase 4)
Renal Insufficiency, Chronic (Phase 2)
Sclerosis (Early Phase 1)
Sports Medicine (Phase 4)
Substance-Related Disorders (Phase 1)
Thalassemia (Phase 1)
Therapeutic Equivalency (Phase 1)
Traumatology (Early Phase 1)
Ultrasonography (Early Phase 1)
Urinary Calculi (Phase 4)
Vaccines (Phase 4)
Vascular Diseases (Phase 3)
Vertigo (Phase 2)
Vestibular Diseases (Phase 3)
Virus Diseases (Phase 4)
Vulvar Diseases (Phase 3)
Vulvodynia (Phase 3)
Trial | Phase | Start Date | Organizations | Indications |
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