Active Ingredient History

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Nifedipine has been formulated as both a long- and short-acting 1,4-dihydropyridine calcium channel blocker. Nifedipine is sold under the brand names Adalat and Procardia among others. Nifedipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. The vasodilatory effects of nifedipine result in an overall decrease in blood pressure. Nifedipine is used for the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud's phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).   NCATS

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Drug Pricing (per unit)

Australia

$0.0653 - $0.2238

United States

$0.1014 - $12.3722
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Note: This drug pricing data is preliminary, incomplete, and may contain errors.

4-(2'-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester | adalat | adalat a.r. | adalat cc | adalate lp | adalat ic | adalat la 20 | adalat la 30 | adalat la 60 | adalat ret | adanif xl | adapin | adapine | adipine mr 10 | adipine mr 20 | adipine xl | afeditab cr | angiopine 10 | angiopine 40 la | angiopine 5 | angiopine mr 10 | angiopine mr 20 | aponal | bay a1040 | bay-a-1040 | calanif | calchan mr 10 | calchan mr 20 | calcilat | cardilate mr | cidoxepin | coracten | coracten sr | coracten xl | coroday mr | doxepin | doxepine | fedipin | fortipine la40 | genalat 10 ret | genalat 20 ret | hypolar ret 10 | hypolar ret 20 | hypolar xl 30 | kentipine | kentipine mr 10 | kentipine mr 20 | nedipin | neozipine xl | nifecard | nifecor | nifedipine | nifedipino | nifedipinum | nifedipres | nifedipress mr 10 | nifedipress mr 20 | nifedotard 20 mr | nifelease | nifensar xl | nife-wolff | nifopress mr | nifopress ret | nimodrel mr 10 | nimodrel mr 20 | nimodrel xl | nivaten ret | p-3693a | procardia | procardia xl | slofedipine xl 30 | slofedipine xl 60 | tensipine mr 10 | tensipine mr 20 | unipine xl | valni 20 ret | valni xl | vasad

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