piperaquine Report issue

Small molecule Experimental
AACT ChEMBL Drug Central MeSH PubChem

Active Ingredient History

NOW
  • Now
Piperaquine is an antiparasitic drug used in combination with dihydroartemisinin to treat malaria. Piperaquine was developed under the Chinese National Malaria Elimination Programme in the 1960s and was adopted throughout China as a replacement for the structurally similar antimalarial drug chloroquine. Due to widespread parasite resistance to piperaquine, the drug fell out of use as a monotherapy, and is instead used as a partner drug for artemisinin combination therapy. Piperaquine kills parasites by disrupting the detoxification of host heme.   Wikipedia

Chemistry

More Chemistry

Pharmacology

  • Mechanisms of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

1,3-bis(1-(7-chloro-4'-quinolyl)-4'-piperazinyl)propane | 1,3-bis(4-(7'-chloro-4'-quinoline)-1-piperazine) | dihydroartemisinin mixture with piperaquine tetraphosphate | piperaquine | piperaquine phosphate | piperaquine phosphate hydrate | piperaquine tetraphosphate | piperaquine tetraphosphate /artenimol | piperaquinoline | quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-)

Organizations (190)

Research & Development (190)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (38)

Approved Indications (1)


 

Malaria

Experimental Indications - Clinical Trial Phases 1-4 (38)


 

Anemia (Phase 4)

Anemia, Sickle Cell (Phase 2/Phase 3)

Cardiotoxicity (Phase 2)

Drug Combinations (Phase 1)

Drug Interactions (Phase 4)

Drugs, Investigational (Phase 2/Phase 3)

Elephantiasis, Filarial (Phase 3)

Fever (Phase 3)

Glucosephosphate Dehydrogenase Deficiency (Phase 4)

Healthy Volunteers (Phase 4)

Helminthiasis (Phase 3)

HIV (Phase 3)

HIV Infections (Phase 4)

Hookworm Infections (Phase 3)

Infections (Phase 2)

Malaria (Phase 4)

Malaria, Falciparum (Phase 4)

Malaria Vaccines (Phase 2)

Malaria, Vivax (Phase 4)

Neoplasm Metastasis (Phase 3)

Parasitemia (Phase 2)

Parasitic Diseases (Phase 4)

Pharmacokinetics (Phase 4)

Pharmacological and Toxicological Phenomena (Phase 2)

Plasmodium (Phase 4)

Plasmodium falciparum (Phase 4)

Plasmodium vivax (Phase 1/Phase 2)

Pregnancy (Phase 4)

Pregnancy Complications (Phase 4)

Scabies (Phase 3)

Stomach Neoplasms (Phase 3)

Strongyloidiasis (Phase 3)

Therapeutics (Phase 3)

Treatment Adherence and Compliance (Phase 4)

Treatment Outcome (Phase 4)

Trichomonas Vaginitis (Phase 3)

Tropical Medicine (Phase 3)

Vaginosis, Bacterial (Phase 3)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 146
  • # of Trial Organizations: 190

Trials by Phase

Trial Phase Start Date Organizations Indications

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