Active Ingredient History
Mesna is an organosulfur compound used as an adjuvant in cancer chemotherapy involving cyclophosphamide and ifosfamide. No clinical drug interaction studies have been conducted with mesna. Mesna concentrates in the bladder where acrolein accumulates after administration of chemotherapy and through a Michael addition, forms a conjugate with acrolein and other urotoxic metabolites. This conjugation reaction inactivates the urotoxic compounds to harmless metabolites. The most common adverse reactions (> 10%) when MESNEX is given with ifosfamide are nausea, vomiting, constipation, leukopenia, fatigue, fever, anorexia, thrombocytopenia, anemia, granulocytopenia, diarrhea, asthenia, abdominal pain, headache, alopecia, and somnolence. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Cystitis (approved 1988)
Acute Kidney Injury (Phase 2/Phase 3)
Adrenal Cortex Neoplasms (Phase 1)
Anemia, Aplastic (Phase 2)
Anemia, Sickle Cell (Phase 2)
Autoimmune Diseases (Phase 2)
Bone Marrow Failure Disorders (Phase 2)
Bone Neoplasms (Phase 2)
Brain Neoplasms (Phase 3)
Breast Neoplasms (Phase 3)
Burkitt Lymphoma (Phase 2)
Carcinoma (Phase 1)
Carcinoma, Embryonal (Phase 2)
Carcinoma, Hepatocellular (Phase 2)
Carcinoma, Non-Small-Cell Lung (Phase 2)
Central Nervous System Neoplasms (Phase 3)
Choriocarcinoma (Phase 2)
Common Variable Immunodeficiency (Phase 2)
Contrast Media (Phase 2)
Creatinine (Phase 2)
Crohn Disease (Phase 2)
Desmoplastic Small Round Cell Tumor (Phase 1)
Esophageal Neoplasms (Phase 1/Phase 2)
Graft vs Host Disease (Phase 2)
Hematologic Diseases (Phase 1)
Hematologic Neoplasms (Phase 2)
Hematopoietic Stem Cell Transplantation (Phase 2)
Hepatoblastoma (Phase 1)
Histiocytosis, Langerhans-Cell (Phase 2)
Hodgkin Disease (Phase 2)
Hypertension, Pulmonary (Phase 2)
Immune System Diseases (Phase 2)
Kidney Failure, Chronic (Phase 2)
Kidney Neoplasms (Phase 1)
Kidney Transplantation (Phase 2)
Leukemia (Phase 3)
Leukemia, Biphenotypic, Acute (Phase 2)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 2)
Leukemia, Lymphoid (Phase 1)
Leukemia-Lymphoma, Adult T-Cell (Phase 1/Phase 2)
Leukemia, Myeloid, Acute (Phase 2)
Leukemia, Myeloid, Chronic-Phase (Phase 2)
Leukemia, Myelomonocytic, Chronic (Phase 2)
Leukemia, Myelomonocytic, Juvenile (Phase 2)
Liver Neoplasms (Phase 1)
Liver Transplantation (Phase 1/Phase 2)
Lung Diseases, Interstitial (Phase 2)
Lung Neoplasms (Phase 3)
Lupus Erythematosus, Systemic (Phase 2)
Lymphoma (Phase 3)
Lymphoma, B-Cell (Phase 2)
Lymphoma, Large B-Cell, Diffuse (Phase 3)
Lymphoma, Large-Cell, Anaplastic (Phase 1)
Lymphoma, Large-Cell, Immunoblastic (Phase 2)
Lymphoma, Mantle-Cell (Phase 2)
Lymphoma, Non-Hodgkin (Phase 2)
Lymphoma, T-Cell (Phase 4)
Lymphoma, T-Cell, Peripheral (Phase 2)
Lymphoproliferative Disorders (Phase 2)
Medulloblastoma (Phase 3)
Melanoma (Phase 2)
Metabolism (Phase 1)
Multiple Myeloma (Phase 2/Phase 3)
Multiple Sclerosis (Phase 2)
Multiple Sclerosis, Relapsing-Remitting (Phase 3)
Muscular Diseases (Phase 1)
Myasthenia Gravis (Phase 1)
Mycoses (Phase 2)
Mycosis Fungoides (Phase 1)
Myelodysplastic Syndromes (Phase 2)
Myeloproliferative Disorders (Phase 2)
Neoplasm Metastasis (Phase 1/Phase 2)
Neoplasm, Residual (Phase 2)
Neoplasms (Phase 2)
Neoplasms, Germ Cell and Embryonal (Phase 2)
Neuroblastoma (Phase 3)
Neurofibrosarcoma (Phase 1)
Neuromyelitis Optica (Phase 2/Phase 3)
Obesity (Phase 1)
Osteosarcoma (Phase 1)
Ovarian Neoplasms (Phase 2)
Pharmacokinetics (Phase 1)
Pleural Effusion (Phase 4)
Primary Immunodeficiency Diseases (Phase 2)
Primary Myelofibrosis (Phase 2)
Renal Insufficiency, Chronic (Phase 2)
Retinoblastoma (Phase 2)
Rhabdoid Tumor (Phase 1)
Rhabdomyosarcoma (Phase 2)
Sarcoma (Phase 3)
Sarcoma, Clear Cell (Phase 1)
Sarcoma, Ewing (Phase 2)
Sarcoma, Myeloid (Phase 2)
Scleroderma, Diffuse (Phase 2)
Scleroderma, Systemic (Phase 3)
Stem Cell Transplantation (Phase 2)
Stiff-Person Syndrome (Phase 1/Phase 2)
Teratoma (Phase 2)
Testicular Neoplasms (Phase 2)
Vasculitis (Phase 1)
Wilms Tumor (Phase 1)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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