Diseases [C] » Nervous System Diseases [C10] » Autoimmune Diseases of the Nervous System » Demyelinating Autoimmune Diseases, CNS » Multiple Sclerosis
Diseases [C] » Nervous System Diseases [C10] » Demyelinating Diseases » Demyelinating Autoimmune Diseases, CNS » Multiple Sclerosis
Diseases [C] » Immune System Diseases [C20] » Autoimmune Diseases » Autoimmune Diseases of the Nervous System » Demyelinating Autoimmune Diseases, CNS » Multiple Sclerosis
Description
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903) MeSH
Hierarchy View
Subtype Terms (2)
Multiple Sclerosis, Chronic Progressive
70 drugs (39 approved, 31 experimental)
Multiple Sclerosis, Relapsing-Remitting
158 drugs (93 approved, 65 experimental)
Approved Indicated Drugs (29)
Phase 4 Indicated Drugs (38)
Phase 3 Indicated Drugs (48)
Phase 2 Indicated Drugs (99)
allogeneic adipose derived mesenchymal stem cell
Anti-thymocyte Globulin (Rabbit) (Thymoglobulin)
autologous bone marrow derived mesenchymal cells
autologous hematopoietic stem cells
Meningococcal (Groups A, C, Y, W) Conjugate Vaccine (MenQuadfi)
Other Experimental Indicated Drugs (22)
Organization Involved with Phase 4 Indications (97)
Adolphe Rothschild Ophtalmologic Foundation
Amphia Hospital Breda, the Netherlands
Badalona Hospital Germans Trias i Pujol
Cantonal Hospital of St. Gallen
Holy Name Medical Center, Teaneck, NJ
Icahn School of Medicine at Mount Sinai
Innovatiefonds Zorgverzekeraars
Katholieke Universiteit Leuven
MidAmerica Neuroscience Research Foundation at Rowe Neurology Institute
MidAmerica Research Foundation
MS Center of Northeastern New York
Multiple Sclerosis Center of Atlanta
Multiple Sclerosis Center of Northeastern New York
National Multiple Sclerosis Society
Neurocenter of Southern Switzerland, Lugano
Patient-Centered Outcomes Research Institute
Rocky Mountain MS Research Group
Social Security Mexican Institute
St. Antonius Hospital, Nieuwegein
State University of New York, Buffalo
The University of Texas, Dallas
University Hospital of North Norway
Organization Involved with Phase 3 Indications (211)
Advanced Neurology Specialists
Advanced Neurosciences Institute
Alabama Neurology Associates, PC
Alta Bates Summit Medical Center
Altru Health System Research Center
Anne Arundel Health System Research Institute
Arizona Neurological Institute
Assistance Publique - Hôpitaux de Paris
Axiom Clinical Research of Florida
Central Jutland Regional Hospital
Central Texas Neurology Consultants
Hoosier Cancer Research Network
Hospital of Central Denmark Region, Viborg, Denmark
Hospital of South West Jutland
Institut fur Klinische Forschung, Germany
Island Neurological Associates, PC
Istituto Don Carlo Gnocchi Divisione Neurologica Riabilitativa. Via Capecelatro 66 20148 Milano
Italian Multiple Sclerosis Foundation
Josephson Wallack Munshower Neurology, PC
Mazandaran University of Medical Sciences
Mercy Multiple Sclerosis Center of Oklahoma Mercy Neuroscience Institute
Multiple Sclerosis Society of Canada
National Center for Research Resources (NCRR)
National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health (NIH)
Negroski, Stein, Sutherland and Hanes Neurology
NeuroCure Clinical Research Center
Neurology Center of New England P.C.
North Central Neurology Associates, PC
Ospedale Maggiore San Giovanni Bosco
Ospedale SAntonio Abate Servizio recupero Neurologico
Phoenix Neurological Associates, LTD
Policlinico Universitario Centro Sclerosi Multipla
Rivermead Rehabilitation Centre
Royal Berkshire and Battle Hospitals NHS Trust
Ruan Neurology Clinical Research Center
Russian State Medical University
Sibyl E. Wray, MD, Neurology, PC
South Shore Neurologic Associates
Springfield Neurology Associates, LLC
Suncoast Neuroscience Associates, Inc.
The Immune Response Corporation
The Multiple Sclerosis Center of Vero Beach
The Multiple Sclerosis National Competence Centre
The Neurological Institute, PA
The Norwegian Multiple sclerosis Society
University of British Columbia
University of California, Davis
University of Missouri, Kansas City
University of Modena and Reggio Emilia
University of Nice Sophia Antipolis
University of Roma La Sapienza
University of Southern California
Vestre Viken Ringerike Sykehus
Organization Involved with Phase 2 Indications (168)
Advancell - Advanced In Vitro Cell Technologies, S.A.
Alberta Innovates Health Solutions
Barnet and Chase Farm Hospitals NHS Trust
Basildon and Thurrock University Hospitals NHS Foundation Trust
Buffalo Neuroimaging Analysis Center
Clinica Universidad de Navarra
Clinique de sclérose en plaques et neuromusculaire de l'Outaouais
Consortium of Multiple Sclerosis Centers
Danish Research Centre for Magnetic Resonance
Fédération Hospitalo-Universitaire NEUROGENYCS
Fundación Universidad Católica de Valencia San Vicente Mártir
German Federal Ministry of Education and Research
Health Sciences Centre Foundation, Manitoba
Institut d'Investigacions Biomèdiques August Pi i Sunyer
Instituto Mexicano del Seguro Social
Manitoba Medical Service Foundation
Methodist Cancer Center, Houston, Texas
Michigan Medical P.C. Neurology
Multiple Sclerosis Society of Great Britain and Northern Ireland
National Center for Complementary and Integrative Health (NCCIH)
National Center of Neurology and Psychiatry, Japan
National Institute for Health Research, United Kingdom
National Institute of Allergy and Infectious Diseases (NIAID)
Novo Cellular Medicine Institute LLP
Ontario Institute for Regenerative Medicine (OIRM)
Pontificia Universidad Catolica de Chile
Presbyterian/St. Luke's Medical Center, Denver
Southend University Hospital Foundation NHS Trust
Sutter East Bay Medical Foundation
Organization Involved with Phase 1 Indications (52)
Casa Sollievo della Sofferenza IRCCS
Case Western Reserve University
Centre for Probe Development and Commercialization
Organization Involved with Other Experimental Indications (24)
Hierarchy Tree View
UMLS Data
YOU AGREE THAT THE INFORMATION PROVIDED ON THIS WEBSITE IS PROVIDED “AS IS”, WITHOUT ANY WARRANTY OF ANY KIND, EXPRESSED OR IMPLIED, INCLUDING WITHOUT LIMITATION WARRANTIES OF MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PURPOSE, OR NON-INFRINGEMENT OF ANY THIRD-PARTY PATENT, COPYRIGHT, OR ANY OTHER THIRD-PARTY RIGHT. IN NO EVENT SHALL THE CREATORS OF THE WEBSITE OR WASHINGTON UNIVERSITY BE LIABLE FOR ANY DIRECT, INDIRECT, SPECIAL, OR CONSEQUENTIAL DAMAGES ARISING OUT OF OR IN ANY WAY CONNECTED WITH THE WEBSITE, THE USE OF THE WEBSITE, OR THIS AGREEMENT, WHETHER IN BREACH OF CONTRACT, TORT OR OTHERWISE, EVEN IF SUCH PARTY IS ADVISED OF THE POSSIBILITY OF SUCH DAMAGES.
