Active Ingredient History
An antibody (Ab) is the secreted form of a B cell receptor; the term immunoglobulin (Ig) can refer to either the membrane-bound form or the secreted form of the B cell receptor, but they are, broadly speaking, the same protein, and so the terms are often treated as synonymous. Antibodies are large, Y-shaped proteins belonging to the immunoglobulin superfamily which are used by the immune system to identify and neutralize foreign objects such as bacteria and viruses, including those that cause disease. Antibodies can recognize virtually any size antigen with diverse chemical compositions from molecules. Each antibody recognizes one or more specific antigens. This term literally means "antibody generator", as it is the presence of an antigen that drives the formation of an antigen-specific antibody. Each tip of the "Y" of an antibody contains a paratope that specifically binds to one particular epitope on an antigen, allowing the two molecules to bind together with precision. Using this mechanism, antibodies can effectively "tag" a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly. Wikipedia
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Hepatitis A (approved 1944)
Hereditary Sensory and Motor Neuropathy (approved 2012)
Purpura, Thrombocytopenic (approved 2013)
Abortion, Habitual (Phase 4)
Abortion, Spontaneous (Phase 2)
Acquired Immunodeficiency Syndrome (Phase 3)
Agammaglobulinemia (Phase 4)
Alzheimer Disease (Phase 3)
Anemia, Sickle Cell (Phase 1/Phase 2)
Anesthesia and Analgesia (Phase 3)
Anthrax (Phase 1/Phase 2)
Antibodies, Monoclonal (Phase 4)
Anxiety Disorders (Phase 3)
Asperger Syndrome (Phase 4)
Asthma (Phase 3)
Autistic Disorder (Phase 4)
Autoimmune Diseases (Phase 4)
Bacteremia (Phase 4)
Bacterial Infections (Phase 3)
Biliary Atresia (Phase 1/Phase 2)
Biomarkers (Phase 4)
BK Virus (Phase 3)
Blood Transfusion (Phase 3)
Brain Injuries, Traumatic (Phase 2)
Bronchiectasis (Phase 4)
Burns (Phase 2/Phase 3)
Carcinoma, Hepatocellular (Phase 3)
Carcinoma, Non-Small-Cell Lung (Phase 1/Phase 2)
Cardiomyopathies (Phase 3)
Cardiovascular Diseases (Phase 2)
Chediak-Higashi Syndrome (Phase 2)
Child (Phase 3)
Child Development Disorders, Pervasive (Phase 4)
Clostridium Infections (Phase 4)
Cocaine-Related Disorders (Phase 1)
Cognition Disorders (Phase 2)
Cognitive Dysfunction (Phase 4)
Colonic Neoplasms (Phase 2)
Common Variable Immunodeficiency (Phase 4)
Community-Acquired Infections (Phase 2)
Corneal Diseases (Phase 1)
Corneal Neovascularization (Phase 1)
Coronary Aneurysm (Phase 2)
COVID-19 (Phase 4)
Cyclosteroids (Phase 3)
Cytomegalovirus Infections (Phase 3)
Deficiency Diseases (Phase 4)
Dementia (Phase 4)
Demyelinating Diseases (Phase 2)
Dental Caries (Phase 3)
Dermatitis, Atopic (Phase 2/Phase 3)
Dermatology (Phase 3)
Dermatomyositis (Phase 3)
Diabetes Complications (Phase 2)
Diabetes Mellitus (Phase 4)
Diabetic Neuropathies (Phase 2)
Diagnosis (Phase 4)
Down Syndrome (Phase 2)
Drug Hypersensitivity (Phase 3)
Drug Therapy (Phase 2/Phase 3)
Dry Eye Syndromes (Phase 2)
Encephalitis (Phase 3)
Encephalitis, Japanese (Phase 2)
Epilepsies, Partial (Phase 2)
Epilepsy (Phase 4)
Erythroblastosis, Fetal (Phase 4)
Fasciitis, Necrotizing (Phase 2)
Fertilization in Vitro (Phase 2)
Fetal Development (Phase 3)
Fournier Gangrene (Phase 2)
Gas Gangrene (Phase 2)
Gastrointestinal Diseases (Phase 2)
Glycogen Storage Disease Type II (Phase 4)
Graft Rejection (Phase 4)
Growth and Development (Phase 4)
Guillain-Barre Syndrome (Phase 4)
Hair (Phase 2)
Healthy Volunteers (Phase 1/Phase 2)
Heart Diseases (Phase 2)
Heart Failure (Phase 1)
Heart Transplantation (Phase 2)
Hepatitis B (Phase 4)
Hepatitis C, Chronic (Phase 3)
Hepatitis, Viral, Human (Phase 3)
Histiocytosis, Langerhans-Cell (Phase 2/Phase 3)
HIV Infections (Phase 4)
Hyperbilirubinemia (Phase 4)
Hyper-IgM Immunodeficiency Syndrome (Phase 4)
Hypertension, Pulmonary (Phase 2)
Hypophosphatasia (Phase 4)
IgG Deficiency (Phase 4)
Immune System Diseases (Phase 4)
Immunity, Humoral (Phase 4)
Immunoglobulin M (Phase 3)
Immunologic Deficiency Syndromes (Phase 3)
Immunosuppression Therapy (Phase 3)
Infant, Low Birth Weight (Phase 2/Phase 3)
Infant, Newborn (Phase 2/Phase 3)
Infant, Premature (Phase 2/Phase 3)
Infant, Small for Gestational Age (Phase 2/Phase 3)
Infections (Phase 4)
Inflammation (Phase 2)
Influenza A virus (Phase 3)
Influenza B virus (Phase 3)
Intracranial Hemorrhage, Hypertensive (Phase 2)
Ischemic Stroke (Phase 1)
Isoantibodies (Phase 1)
Kidney Diseases (Phase 2/Phase 3)
Kidney Failure, Chronic (Phase 4)
Kidney Transplantation (Phase 4)
Leukemia (Phase 2)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 3)
Limbic Encephalitis (Phase 2)
Liver Cirrhosis (Phase 3)
Liver Diseases (Phase 3)
Liver Transplantation (Phase 2)
Lung Diseases, Interstitial (Phase 2)
Lung Transplantation (Phase 2)
Lupus Erythematosus, Cutaneous (Early Phase 1)
Lupus Erythematosus, Systemic (Phase 2/Phase 3)
Lymphohistiocytosis, Hemophagocytic (Phase 3)
Lymphoma (Phase 2)
Lymphoproliferative Disorders (Phase 2)
Macular Degeneration (Phase 2)
Melanoma (Phase 2)
Motor Neuron Disease (Phase 3)
Mucocutaneous Lymph Node Syndrome (Phase 4)
Mucopolysaccharidoses (Phase 4)
Mucopolysaccharidosis II (Phase 4)
Multiple Myeloma (Phase 2)
Multiple Sclerosis (Phase 3)
Multiple Sclerosis, Relapsing-Remitting (Phase 3)
Multiple System Atrophy (Phase 2)
Muscle Rigidity (Phase 1)
Musculoskeletal Diseases (Phase 1)
Myasthenia Gravis (Phase 4)
Myelitis, Transverse (Phase 3)
Myelodysplastic Syndromes (Phase 2)
Myeloproliferative Disorders (Phase 2)
Myocardial Infarction (Phase 3)
Neonatal Sepsis (Phase 3)
Neonatology (Early Phase 1)
Neoplasms (Phase 2/Phase 3)
Neoplasms, Plasma Cell (Phase 1/Phase 2)
Neoplastic Syndromes, Hereditary (Phase 2)
Nerve Degeneration (Phase 3)
Neuralgia (Phase 2)
Neuroblastoma (Phase 3)
Neurodevelopmental Disorders (Phase 3)
Neuroinflammatory Diseases (Phase 2)
Neuromyelitis Optica (Phase 3)
Obsessive-Compulsive Disorder (Phase 3)
Optic Neuritis (Phase 3)
Pain (Phase 3)
Paraproteinemias (Phase 2)
Parvovirus B19, Human (Phase 3)
Pediatrics (Phase 2)
Pemphigoid, Bullous (Phase 3)
Pemphigus (Phase 2)
Peripheral Nervous System Diseases (Phase 4)
Plasmapheresis (Phase 4)
Pneumonia (Phase 3)
Polymyositis (Phase 3)
Polyradiculoneuropathy (Phase 4)
Postpoliomyelitis Syndrome (Phase 3)
Postural Orthostatic Tachycardia Syndrome (Phase 1/Phase 2)
Pregnancy (Phase 3)
Pregnancy Complications (Phase 2)
Primary Immunodeficiency Diseases (Phase 4)
Prostheses and Implants (Phase 2)
Psychiatry (Phase 4)
Psychotic Disorders (Phase 2)
Pulmonary Disease, Chronic Obstructive (Phase 2)
Purpura (Phase 3)
Purpura, Thrombocytopenic, Idiopathic (Phase 4)
Radiation Pneumonitis (Phase 2)
Renal Insufficiency (Phase 2)
Respiratory Distress Syndrome (Phase 3)
SARS-CoV-2 (Phase 2/Phase 3)
Schizophrenia (Phase 4)
Scleroderma, Diffuse (Phase 2)
Scleroderma, Systemic (Phase 3)
Sepsis (Phase 3)
Severe Acute Respiratory Syndrome (Phase 4)
Severe Combined Immunodeficiency (Phase 3)
Shock, Septic (Phase 3)
Signs and Symptoms, Digestive (Phase 2)
Small Fiber Neuropathy (Phase 4)
Soft Tissue Infections (Phase 2)
Spasm (Phase 1)
Spinocerebellar Ataxias (Phase 2)
Spinocerebellar Degenerations (Phase 2)
Staphylococcal Infections (Phase 4)
Stevens-Johnson Syndrome (Phase 3)
Stiff-Person Syndrome (Phase 3)
Streptococcal Infections (Phase 4)
Streptococcus (Phase 3)
Substance-Related Disorders (Phase 1)
Therapeutics (Phase 4)
Thrombocytopenia (Phase 4)
Thrombosis (Phase 2)
Unverricht-Lundborg Syndrome (Phase 3)
Urologic Neoplasms (Phase 2)
Urticaria (Phase 2)
Venous Cutdown (Phase 3)
Viremia (Phase 4)
Viruses (Phase 3)
West Nile virus (Phase 1/Phase 2)
Whooping Cough (Phase 3)
Wiskott-Aldrich Syndrome (Phase 4)
Trial | Phase | Start Date | Organizations | Indications |
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