Motor Neuron Disease D016472

Diseases [C] » Nervous System Diseases [C10] » Neurodegenerative Diseases » Motor Neuron Disease

Diseases [C] » Nervous System Diseases [C10] » Neuromuscular Diseases » Motor Neuron Disease

Description

Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)   MeSH

Hierarchy View

Subtype Terms (3)

Amyotrophic Lateral Sclerosis
178 drugs (82 approved, 96 experimental)

Bulbar Palsy, Progressive
1 experimental drug

Muscular Atrophy, Spinal
31 drugs (20 approved, 11 experimental)


Approved Indicated Drugs (3)

Phase 4 Indicated Drugs (3)

Phase 2 Indicated Drugs (100)

Key: D016472 (91) Subtype (9)


Organization Involved with Phase 4 Indications (4)

Organization Involved with Phase 2 Indications (99)

Key: D016472 (84) Subtype (15)

Hierarchy Tree View

UMLS Data


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