Related MeSH Hierarchy (4)
Diseases [C] » Musculoskeletal Diseases [C05] » Muscular Diseases » Myositis » Polymyositis » Dermatomyositis
Diseases [C] » Nervous System Diseases [C10] » Neuromuscular Diseases » Muscular Diseases » Myositis » Polymyositis » Dermatomyositis
Diseases [C] » Skin and Connective Tissue Diseases [C17] » Connective Tissue Diseases » Dermatomyositis
Diseases [C] » Skin and Connective Tissue Diseases [C17] » Skin Diseases » Dermatomyositis
Description
A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6) MeSH
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Approved Indicated Drugs (1)
Phase 2 Indicated Drugs (25)
Phase 1 Indicated Drugs (5)
Other Experimental Indicated Drugs (5)
Organization Involved with Phase 4 Indications (8)
Organization Involved with Phase 3 Indications (18)
Organization Involved with Phase 2 Indications (15)
Organization Involved with Phase 1 Indications (9)
Organization Involved with Other Experimental Indications (3)
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