Dermatomyositis D003882

Related MeSH Hierarchy (4)

Diseases [C] » Musculoskeletal Diseases [C05] » Muscular Diseases » Myositis » Polymyositis » Dermatomyositis

Diseases [C] » Nervous System Diseases [C10] » Neuromuscular Diseases » Muscular Diseases » Myositis » Polymyositis » Dermatomyositis

Diseases [C] » Skin and Connective Tissue Diseases [C17] » Connective Tissue Diseases » Dermatomyositis

Diseases [C] » Skin and Connective Tissue Diseases [C17] » Skin Diseases » Dermatomyositis

Description

A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)   MeSH

Approved Indicated Drugs (1)

Phase 1 Indicated Drugs (3)


Organization Involved with Other Experimental Indications (3)

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UMLS Data


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