biotin Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Biotin (also known as vitamin H and vitamin B7) is a water-soluble vitamin which is required for normal cellular functions, growth and development. Biotin is an important cofactor for many mitochondria and cytoplasm enzymes: acetyl-CoA carboxylase a (ACCa),7 ACCb, pyruvate carboxylase (PC), propionyl-CoA carboxylase (PCC), and methylcrotonyl-CoA carboxylase (MCC) and plays critical role in in the intermediate metabolism of gluconeogenesis, fatty acid synthesis, and amino acid catabolism. The vitamin cannot be synthesized by humans and must be obtained from diet. If there is a lack of biotin, an organism starts suffering from biotin deficiency, a condition which is very common among pregnant women, for example. The vitamin deficiency effects hair, nail growth and skin health. For preventing measures, biotin should be taken as a dietary supplement (in a form of vitamin complex or as a pure biotin) which are marketed worldwide under different names. Biotin is a part of many formulations which were approved by FDA.   NCATS

Chemistry

  • SMILES: OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12
  • InChIKey: YBJHBAHKTGYVGT-ZKWXMUAHSA-N
  • Mol. Mass: 244.311
  • ALogP: 0.8
  • ChEMBL Molecule:
    biotin  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Parenteral
  • Pro Drug: No

Alternative names

(3as,4s,6ar)-hexahydro-2-oxo-1h-thieno[3,4-d]imidazole-4-valeric acid | 5-(2-oxohexahydro-1h-thieno[3,4-d]imidazol-4-yl)pentanoic acid | bioepiderm | biotin | biotin 100 | biotina | biotine | biotinum | (+)-cis-hexahydro-2-oxo-1h-thieno[3,4]imidazole-4-valeric acid | cis-hexahydro-2-oxo-1h-thieno(3,4)imidazole-4-valeric acid | cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid | cis-(+)-tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid | coenzyme r | d-biotin | d-(+)-biotin | d(+)-biotin | vitamin b7 | vitamin h

Organizations (41)

Research & Development (34)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (7)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (26)

Approved Indications (6)


 

Anemia

Anemia, Iron-Deficiency

Avitaminosis (approved 2000)

Diabetes Mellitus, Type 2

Kidney Failure, Chronic

Vitamin B Deficiency

Experimental Indications - Clinical Trial Phases 1-4 (21)


 

Adrenoleukodystrophy (Phase 2/Phase 3)

Amyotrophic Lateral Sclerosis (Phase 2)

Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E] (Phase 4)

Anemia ()

Anemia, Sickle Cell (Early Phase 1)

Asthma (Phase 3)

Biotin (Phase 4)

Charcot-Marie-Tooth Disease (Phase 1/Phase 2)

Diabetes Mellitus (Phase 3)

Drugs, Investigational (Phase 1/Phase 2)

Healthy Volunteers (Phase 1)

Huntington Disease (Phase 2)

Hyperglycemia (Phase 3)

Kidney Diseases (Phase 1)

Liver Diseases (Phase 1)

Metabolic Syndrome (Phase 3)

Motor Neuron Disease (Phase 2)

Multiple Sclerosis (Phase 3)

Peripheral Nervous System Diseases (Phase 1/Phase 2)

Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (Phase 1/Phase 2)

Prediabetic State (Phase 3)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 29
  • # of Trial Organizations: 34

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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