Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Neoplasm Proteins » Oncogene Proteins » Proto-Oncogene Proteins
Description
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity. MeSH
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Subtype Terms (65)
Cyclin D1
9 approved drugs
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
MDS1 and EVI1 Complex Locus Protein
Myeloid-Lymphoid Leukemia Protein
N-Myc Proto-Oncogene Protein
10 drugs (8 approved, 2 experimental)
Pre-B-Cell Leukemia Transcription Factor 1
Proto-Oncogene Proteins c-akt
1 experimental drug
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogene Proteins c-bcl-6
Proto-Oncogene Proteins c-kit
3 approved drugs
Proto-Oncogene Proteins c-mdm2
Proto-Oncogene Proteins c-met
18 drugs (13 approved, 5 experimental)
Proto-Oncogene Proteins p21(ras)
10 drugs (7 approved, 3 experimental)
Proto-Oncogene Proteins pp60(c-src)
Receptor, ErbB-2
3 experimental drugs
Receptor, Fibroblast Growth Factor, Type 3
3 experimental drugs
Receptor, Macrophage Colony-Stimulating Factor
RUNX1 Translocation Partner 1 Protein
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