Related MeSH Hierarchy (8)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Intracellular Signaling Peptides and Proteins » Protein-Tyrosine Kinases » Receptor Protein-Tyrosine Kinases » ErbB Receptors » Receptor, ErbB-2
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Neoplasm Proteins » Oncogene Proteins » Proto-Oncogene Proteins » Receptor, ErbB-2
Chemicals and Drugs [D] » Biological Factors [D23] » Antigens » Antigens, Surface » Histocompatibility Antigens » Minor Histocompatibility Antigens » Receptor, ErbB-2
Chemicals and Drugs [D] » Biological Factors [D23] » Antigens » Isoantigens » Histocompatibility Antigens » Minor Histocompatibility Antigens » Receptor, ErbB-2
Chemicals and Drugs [D] » Biological Factors [D23] » Biomarkers » Biomarkers, Tumor » Receptor, ErbB-2
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Receptors, Cell Surface » Receptors, Peptide » Receptors, Growth Factor » ErbB Receptors » Receptor, ErbB-2
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Transferases » Phosphotransferases » Phosphotransferases (Alcohol Group Acceptor) » Protein Kinases » Protein-Tyrosine Kinases » Receptor Protein-Tyrosine Kinases » ErbB Receptors » Receptor, ErbB-2
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Receptors, Cell Surface » Receptor Protein-Tyrosine Kinases » ErbB Receptors » Receptor, ErbB-2
Description
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member. MeSH
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