Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Carrier Proteins » RNA-Binding Proteins » RNA Recognition Motif Proteins » Heterogeneous-Nuclear Ribonucleoproteins » RNA-Binding Protein FUS
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Neoplasm Proteins » Oncogene Proteins » Proto-Oncogene Proteins » RNA-Binding Protein FUS
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Nucleoproteins » RNA-Binding Proteins » RNA Recognition Motif Proteins » Heterogeneous-Nuclear Ribonucleoproteins » RNA-Binding Protein FUS
Description
A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia. MeSH
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