Active Ingredient History
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5–16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes. The major sources of IL-2 are activated CD4+ T cells and activated CD8+ T cells. Put shortly the function of IL-2 is to stimulate the growth of helper, cytotoxic and regulatory T cells. Wikipedia
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Carcinoma, Renal Cell (approved 1992)
Abdominal Wall (Early Phase 1)
Abortion, Habitual (Phase 1/Phase 2)
Acquired Immunodeficiency Syndrome (Phase 2)
Acute Coronary Syndrome (Phase 2)
Adenocarcinoma (Phase 2)
Adenocarcinoma of Lung (Phase 1/Phase 2)
Alopecia Areata (Phase 3)
Alphapapillomavirus (Phase 1)
Alzheimer Disease (Phase 2)
Amputation, Traumatic (Early Phase 1)
Amyotrophic Lateral Sclerosis (Phase 2)
Anemia, Hemolytic, Autoimmune (Phase 1/Phase 2)
Anemia, Refractory (Phase 3)
Anus Neoplasms (Phase 2)
Arthritis, Rheumatoid (Phase 2)
Astrocytoma (Phase 1/Phase 2)
Autoimmune Diseases (Phase 1/Phase 2)
Behcet Syndrome (Phase 2)
Biomarkers (Phase 1)
Bipolar Disorder (Phase 2)
Bone Marrow Cells (Phase 1/Phase 2)
Bone Neoplasms (Phase 1)
Brain Neoplasms (Phase 2)
Breast Neoplasms (Phase 3)
Breast Neoplasms, Male (Phase 2)
Burkitt Lymphoma (Phase 3)
Carcinoma (Phase 1/Phase 2)
Carcinoma, Adenosquamous (Phase 2)
Carcinoma, Giant Cell (Phase 2)
Carcinoma, Hepatocellular (Phase 2/Phase 3)
Carcinoma in Situ (Phase 1)
Carcinoma, Merkel Cell (Phase 1/Phase 2)
Carcinoma, Non-Small-Cell Lung (Phase 2)
Carcinoma, Ovarian Epithelial (Phase 1)
Carcinoma, Renal Cell (Phase 3)
Carcinoma, Squamous Cell (Phase 2)
Carcinoma, Transitional Cell (Phase 2)
Cells (Phase 2)
Cervical Intraepithelial Neoplasia (Phase 1)
Cholangiocarcinoma (Phase 1/Phase 2)
Cholangitis, Sclerosing (Phase 2)
Chondrosarcoma (Phase 2)
Chronic Urticaria (Phase 2/Phase 3)
Colitis, Ulcerative (Phase 2)
Colonic Neoplasms (Phase 1/Phase 2)
Colorectal Neoplasms (Phase 2)
Conjunctivitis (Phase 2)
COVID-19 (Phase 3)
Crohn Disease (Phase 2)
Cryoglobulinemia (Phase 1/Phase 2)
Cytomegalovirus Infections (Phase 1/Phase 2)
Cytomegalovirus Retinitis (Phase 1)
Depression (Phase 4)
Dermatology (Phase 2)
Dermatomyositis (Phase 3)
Diabetes Mellitus (Phase 1/Phase 2)
Diabetes Mellitus, Type 1 (Phase 2)
Drugs, Investigational (Phase 2)
Encephalitis (Phase 1/Phase 2)
Endometrial Neoplasms (Phase 2)
Ependymoma (Phase 1)
Esophageal Neoplasms (Phase 2)
Eye Neoplasms (Phase 1)
Facial Injuries (Early Phase 1)
Fallopian Tube Neoplasms (Phase 2)
Gallbladder Neoplasms (Phase 1/Phase 2)
Gastrointestinal Neoplasms (Phase 1/Phase 2)
General Surgery (Phase 2)
Genital Neoplasms, Female (Phase 1/Phase 2)
Gestational Trophoblastic Disease (Phase 2)
Giant Cell Tumor of Bone (Phase 2)
Glioblastoma (Phase 1/Phase 2)
Glioma (Phase 1/Phase 2)
Gliosarcoma (Phase 1/Phase 2)
Graft vs Host Disease (Phase 3)
Granulomatosis with Polyangiitis (Phase 2)
Hamartoma (Phase 2)
Head and Neck Neoplasms (Phase 3)
Healthy Volunteers (Phase 1)
Hematologic Diseases (Phase 1)
Hematologic Neoplasms (Phase 1)
Hematopoietic Stem Cell Transplantation (Phase 1/Phase 2)
Hepatitis A (Phase 3)
Hepatitis, Autoimmune (Phase 2)
Hepatitis B (Phase 3)
Hepatitis B, Chronic (Phase 4)
Hepatitis C (Phase 1)
Hepatitis C, Chronic (Phase 2)
HIV (Phase 4)
HIV Infections (Phase 3)
Hodgkin Disease (Phase 2)
Human papillomavirus 16 (Phase 1)
Hypoglycemia (Phase 1/Phase 2)
Immunosuppression Therapy (Phase 2)
Inflammatory Breast Neoplasms (Phase 2)
Interleukin-2 (Phase 2)
Intestinal Neoplasms (Phase 2)
Kidney (Phase 1/Phase 2)
Kidney Diseases (Phase 2)
Kidney Neoplasms (Phase 4)
Kidney Transplantation (Phase 3)
Leiomyosarcoma (Phase 2)
Leukemia (Phase 3)
Leukemia, Eosinophilic, Acute (Phase 3)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 2)
Leukemia, Lymphoid (Phase 2)
Leukemia-Lymphoma, Adult T-Cell (Phase 1/Phase 2)
Leukemia, Megakaryoblastic, Acute (Phase 1/Phase 2)
Leukemia, Monocytic, Acute (Phase 3)
Leukemia, Myeloid (Phase 2)
Leukemia, Myeloid, Acute (Phase 4)
Leukemia, Myeloid, Chronic-Phase (Phase 2)
Leukemia, Myelomonocytic, Acute (Phase 3)
Leukemia, Myelomonocytic, Chronic (Phase 3)
Leukemia, Myelomonocytic, Juvenile (Phase 2)
Liposarcoma (Phase 1)
Liver Diseases (Phase 4)
Liver Neoplasms (Phase 2)
Liver Transplantation (Phase 2)
Lung Neoplasms (Phase 2)
Lupus Erythematosus, Systemic (Phase 3)
Lupus Nephritis (Phase 3)
Lymphocytes (Phase 1)
Lymphoma (Phase 3)
Lymphoma, B-Cell (Phase 1)
Lymphoma, B-Cell, Marginal Zone (Phase 1)
Lymphoma, Follicular (Phase 3)
Lymphoma, Large B-Cell, Diffuse (Phase 1/Phase 2)
Lymphoma, Large-Cell, Immunoblastic (Phase 3)
Lymphoma, Mantle-Cell (Phase 1)
Lymphoma, Non-Hodgkin (Phase 2/Phase 3)
Lymphoma, T-Cell (Phase 1/Phase 2)
Lymphoma, T-Cell, Peripheral (Phase 2)
Macrophage Activation Syndrome (Phase 1/Phase 2)
Melanoma (Phase 4)
Melanoma, Experimental (Phase 2)
Meninges (Phase 1)
Meningioma (Phase 2)
Mesothelioma (Phase 2)
Mesothelioma, Malignant (Phase 1)
Multiple Myeloma (Phase 2)
Multiple Sclerosis, Relapsing-Remitting (Phase 2)
Myelodysplastic Syndromes (Phase 3)
Myeloproliferative Disorders (Phase 2)
Myositis (Phase 2)
Nasopharyngeal Carcinoma (Phase 1/Phase 2)
Neoplasm Metastasis (Phase 2)
Neoplasms (Phase 3)
Nephrotic Syndrome (Phase 1/Phase 2)
Neuroblastoma (Phase 3)
Neuroectodermal Tumors, Primitive (Phase 1)
Neuroendocrine Tumors (Phase 2)
Oligodendroglioma (Phase 1)
Oropharyngeal Neoplasms (Phase 2)
Osteosarcoma (Phase 2)
Ovarian Diseases (Phase 2)
Ovarian Neoplasms (Phase 2)
Pancreatic Neoplasms (Phase 2)
Papillomavirus Infections (Phase 1)
Pemphigus (Phase 2)
Penile Neoplasms (Phase 2)
Pharmacology (Phase 1)
Polychondritis, Relapsing (Phase 2)
Polycythemia Vera (Phase 1/Phase 2)
Polymyalgia Rheumatica (Phase 2)
Precancerous Conditions (Phase 2)
Prostatic Neoplasms (Phase 2)
Psoriasis (Phase 2)
Purpura, Thrombocytopenic, Idiopathic (Phase 2)
Rectal Neoplasms (Phase 2)
Rhabdomyosarcoma (Phase 2)
Sarcoma (Phase 2)
Sarcoma, Ewing (Phase 2)
Sarcoma, Myeloid (Phase 2)
Sarcoma, Synovial (Phase 1/Phase 2)
Scleroderma, Systemic (Phase 2)
Sepsis (Phase 2)
Sezary Syndrome (Phase 1/Phase 2)
Sjogren's Syndrome (Phase 2)
Skin Neoplasms (Phase 3)
Small Cell Lung Carcinoma (Phase 1/Phase 2)
Spondylitis, Ankylosing (Phase 2)
Squamous Cell Carcinoma of Head and Neck (Phase 2)
Squamous Intraepithelial Lesions (Phase 1)
Stomach Neoplasms (Phase 2)
Takayasu Arteritis (Phase 2)
Testicular Neoplasms (Phase 2)
Thrombocythemia, Essential (Phase 1/Phase 2)
Thrombocytopenia (Phase 1)
Thyroid Neoplasms (Phase 2)
Tissue Donors (Phase 1/Phase 2)
Transplantation (Phase 4)
Traumatology (Early Phase 1)
Triple Negative Breast Neoplasms (Phase 2)
Tuberculosis (Phase 2/Phase 3)
Tuberculosis, Pulmonary (Phase 4)
Urinary Bladder Neoplasms (Phase 1/Phase 2)
Urogenital Neoplasms (Phase 1)
Uterine Cervical Neoplasms (Phase 2)
Vaccination (Phase 2)
Vaginal Neoplasms (Phase 2)
Vulvar Diseases (Phase 1)
Vulvar Neoplasms (Phase 1/Phase 2)
Waldenstrom Macroglobulinemia (Phase 1)
Wiskott-Aldrich Syndrome (Phase 1)
WT1 Proteins (Phase 1/Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
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