ubiquinol Report issue

Small molecule Experimental
AACT DrugBank MeSH PubChem

Active Ingredient History

NOW
  • Now
UBIQUINOL is a reduced form of coenzyme Q10, a lipid-soluble molecule that consists of an aromatic ring and a 10-unit isoprenoid chain. It is naturally produced by the body. A significant increase in plasma CoQ10 status observed after supplementation in one study suggested that UBIQUINOL is a better supplemental form to enhance the CoQ10 status than ubiquinone (the oxidized form of Q10). UBIQUINOL has also been found to reduce oxidative stress induced by strenuous exercise. Oxidative stress is associated with aging and many chronic diseases, such as cardiovascular diseases, cancers, and cognitive decline. Ubiquinol has furthermore been shown to improve mitochondrial oxidative metabolism in the brain, and cognitive improvement was found as a result of Ubiquinol intake in chronic fatigue syndrome patients. UBIQUINOL is considered safe, but can have side effects such as upper abdominal pain, loss of appetite, nausea, diarrhea and headaches. CoQ10 might make blood-thinning drugs, such as warfarin (Coumadin, Jantoven), less effective. This could increase the risk of a blood clot.   NCATS

Chemistry

  • SMILES: COC1=C(OC)C(O)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(C)=C1O
  • InChIKey: QNTNKSLOFHEFPK-UPTCCGCDSA-N
  • Mol. Mass: 865.3594
  • ALogP: Missing data
  • ChEMBL Molecules: Missing data
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Missing data
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: Missing data

Alternative names

ubiquinol | ubiquinol 0 | ubiquinol 1 | ubiquinol 50 | ubiquinol 6 (ubiquinol 30) | ubiquinol 7 | ubiquinol 9 | ubiquinols | ubiquinone hydroquinone

Organizations (18)

Research & Development (18)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (15)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (15)


 

Diabetes Mellitus (Phase 2/Phase 3)

Down Syndrome (Phase 2)

Drugs, Investigational (Phase 3)

Fatigue Syndrome, Chronic (Phase 3)

Gulf War (Phase 3)

Heart Arrest (Phase 2)

Heart Failure (Phase 2)

Huntington Disease (Phase 1)

Infertility, Male (Phase 2)

Inflammation (Phase 2/Phase 3)

Oxidative Stress (Phase 2/Phase 3)

Parkinson Disease (Phase 2)

Polycystic Ovary Syndrome (Phase 2/Phase 3)

Sepsis (Phase 2)

Sprains and Strains (Phase 2/Phase 3)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 17
  • # of Trial Organizations: 18

Trials by Phase

Trial Phase Start Date Organizations Indications

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