Related MeSH Hierarchy (4)
Diseases [C] » Neoplasms [C04] » Neoplasms by Histologic Type » Neoplasms, Plasma Cell » Immunoglobulin Light-chain Amyloidosis
Diseases [C] » Nutritional and Metabolic Diseases [C18] » Metabolic Diseases » Proteostasis Deficiencies » Amyloidosis » Immunoglobulin Light-chain Amyloidosis
Diseases [C] » Immune System Diseases [C20] » Immunoproliferative Disorders » Lymphoproliferative Disorders » Immunoglobulin Light-chain Amyloidosis
Diseases [C] » Immune System Diseases [C20] » Immunoproliferative Disorders » Paraproteinemias » Immunoglobulin Light-chain Amyloidosis
Description
A nonproliferative disorder of the PLASMA CELL characterized by excessive production and misfolding of IMMUNOGLOBULIN LIGHT CHAINS that form insoluble amyloid fibrils (see AMYLOID DEPOSITS) in various tissues. Clinical features include LIVER FAILURE; MULTIPLE MYELOMA; NEPHROTIC SYNDROME; RESTRICTIVE CARDIOMYOPATHY, and neuropathies. MeSH
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Phase 4 Indicated Drugs (2)
Phase 2 Indicated Drugs (16)
Phase 1 Indicated Drugs (5)
Other Experimental Indicated Drugs (13)
Organization Involved with Phase 4 Indications (1)
Organization Involved with Phase 3 Indications (12)
Organization Involved with Phase 2 Indications (34)
Cancer and Leukemia Group B (CALGB)
Eastern Cooperative Oncology Group
Herbert Irving Comprehensive Cancer Center
Hoosier Cancer Research Network
Icahn School of Medicine at Mount Sinai
Memorial Sloan-Kettering Cancer Center
Organization Involved with Phase 1 Indications (6)
Organization Involved with Other Experimental Indications (6)
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UMLS Data
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