Active Ingredient History
Foscarnet is an antiviral agent. Foscarnet shows activity against human herpesviruses and HIV. Foscarnet is used for treating eye problems caused by CMV in people with AIDS. It is also used to treat a type of HSV that cannot be treated by another medicine in people with a weak immune system. FOSCAVIR is the brand name for foscarnet sodium. FOSCAVIR is an organic analogue of inorganic pyrophosphate that inhibits replication of herpesviruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). FOSCAVIR exerts its antiviral activity by a selective inhibition at the pyrophosphate binding site on virusspecific DNA polymerases at concentrations that do not affect cellular DNA polymerases. FOSCAVIR does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to FOSCAVIR. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Cytomegalovirus Retinitis (approved 1991)
Acne Vulgaris (Phase 2)
Acquired Immunodeficiency Syndrome (Phase 3)
Brain Diseases (Phase 1)
Cytomegalovirus Infections (Phase 4)
Cytomegalovirus Retinitis (Phase 4)
Gastrointestinal Diseases (Phase 3)
Graft vs Host Disease (Phase 2)
Hematologic Diseases (Phase 4)
Herpes Simplex (Phase 3)
Herpes Zoster (Phase 4)
HIV Infections (Phase 4)
Hypocalcemia (Phase 4)
Radiculopathy (Phase 1)
| Trial | Phase | Start Date | Organizations | Indications |
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