Active Ingredient History
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances from becoming incorporated into DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand. Fluorouracil is used for the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Breast Neoplasms (approved 1962)
Colonic Neoplasms (approved 1962)
Stomach Neoplasms (approved 1962)
Abdominal Neoplasms (Phase 2)
Acute Kidney Injury (Phase 2)
Adenocarcinoma (Phase 3)
Adenoma, Islet Cell (Phase 2/Phase 3)
Anemia (Phase 1)
Antibody-Dependent Cell Cytotoxicity (Phase 2)
Antimetabolites (Phase 2)
Antineoplastic Agents (Phase 3)
Anus Neoplasms (Phase 3)
Appendiceal Neoplasms (Phase 1)
Appendix (Phase 2)
Ascites (Phase 2)
Ascorbic Acid (Phase 3)
Basal Cell Nevus Syndrome (Phase 1/Phase 2)
Bevacizumab (Phase 1/Phase 2)
Bile Duct Neoplasms (Phase 2/Phase 3)
Biliary Tract Diseases (Phase 2)
Biliary Tract Neoplasms (Phase 3)
Biopsy (Phase 2)
Bone Marrow Diseases (Phase 3)
Bowen's Disease (Phase 4)
Breast Neoplasms (Phase 4)
Capecitabine (Phase 2)
Carcinoid Tumor (Phase 2)
Carcinoma (Phase 4)
Carcinoma, Adenoid Cystic (Phase 1)
Carcinoma, Basal Cell (Phase 4)
Carcinoma, Hepatocellular (Phase 3)
Carcinoma, Islet Cell (Phase 2)
Carcinoma, Mucoepidermoid (Phase 1)
Carcinoma, Neuroendocrine (Phase 2)
Carcinoma, Non-Small-Cell Lung (Phase 2)
Carcinoma, Ovarian Epithelial (Phase 1)
Carcinoma, Pancreatic Ductal (Phase 2)
Carcinoma, Renal Cell (Phase 2)
Carcinoma, Squamous Cell (Phase 4)
Carcinoma, Transitional Cell (Phase 3)
Carcinoma, Verrucous (Phase 3)
Cardiotoxicity (Phase 3)
Cervical Intraepithelial Neoplasia (Phase 1)
Cetuximab (Phase 2)
Chalazion (Phase 3)
Chemoradiotherapy (Phase 3)
Chemotherapy, Adjuvant (Phase 3)
Child (Phase 2)
Cholangiocarcinoma (Phase 4)
Chondrosarcoma (Phase 1)
Choriocarcinoma (Phase 1)
Circulating Tumor DNA (Phase 2)
Cognition Disorders (Phase 3)
Colonic Diseases (Phase 2)
Colonic Neoplasms (Phase 4)
Colorectal Neoplasms (Phase 4)
Corneal Diseases (Phase 4)
Cytokine-Induced Killer Cells (Phase 4)
Dacryocystorhinostomy (Phase 1)
Dermatology (Phase 4)
Diarrhea (Phase 2)
Digestive System Neoplasms (Phase 3)
Disseminated Intravascular Coagulation (Phase 2)
DNA Repair-Deficiency Disorders (Phase 3)
Docetaxel (Phase 2/Phase 3)
Drugs, Investigational (Phase 3)
Drug Therapy (Phase 3)
Ectropion (Early Phase 1)
Endometrial Neoplasms (Phase 2)
Ependymoma (Phase 1)
Epidermal Growth Factor (Phase 2)
Epstein-Barr Virus Infections (Phase 2/Phase 3)
Esophageal Diseases (Phase 3)
Esophageal Neoplasms (Phase 4)
Esophageal Squamous Cell Carcinoma (Phase 3)
Esophagogastric Junction (Phase 3)
Exanthema (Phase 2)
Eyebrows (Phase 3)
Fallopian Tube Neoplasms (Phase 2)
Fever (Phase 3)
Fluorouracil (Phase 4)
Gallbladder Neoplasms (Phase 3)
Gastrointestinal Diseases (Phase 1/Phase 2)
Gastrointestinal Neoplasms (Phase 3)
Gastrointestinal Stromal Tumors (Phase 1)
General Surgery (Phase 3)
Genes, erbB-2 (Phase 2)
Geriatrics (Phase 3)
Germinoma (Phase 1)
Glaucoma (Phase 4)
Glaucoma, Open-Angle (Phase 4)
Glioblastoma (Phase 1/Phase 2)
Glioma (Phase 1)
Graft vs Host Disease (Phase 2)
Granuloma (Phase 1)
Hamartoma (Phase 3)
Head and Neck Neoplasms (Phase 4)
Hematologic Diseases (Phase 3)
Hepatoblastoma (Phase 3)
HIV Infections (Phase 3)
Hodgkin Disease (Phase 1)
Hospital Costs (Phase 3)
Human papillomavirus 16 (Phase 2)
Hyperthermia (Phase 2)
Hypopharyngeal Neoplasms (Phase 3)
Immune Checkpoint Inhibitors (Phase 2)
Immunotherapy (Phase 3)
Inflammatory Breast Neoplasms (Phase 3)
Intestinal Diseases (Phase 2)
Intestinal Neoplasms (Phase 3)
Irinotecan (Phase 2/Phase 3)
Keloid (Phase 4)
Keratosis, Actinic (Phase 4)
Kidney (Phase 1/Phase 2)
Kidney Neoplasms (Phase 3)
Klatskin Tumor (Phase 2)
Lapatinib (Phase 3)
Laryngeal Neoplasms (Phase 3)
Length of Stay (Phase 3)
Leukemia (Phase 1)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 1)
Leukemia, Myeloid, Acute (Phase 1)
Leukemia, Myeloid, Chronic-Phase (Phase 1)
Leukemia, Myelomonocytic, Chronic (Phase 1)
Leukoplakia, Oral (Phase 1)
Liver Diseases (Phase 2)
Liver Neoplasms (Phase 4)
Liver Transplantation (Phase 3)
Lung Neoplasms (Phase 2/Phase 3)
Lymphoma (Phase 2)
Lymphoma, Non-Hodgkin (Phase 1)
Melanoma (Phase 1)
Mesothelioma (Phase 2)
Microsatellite Instability (Phase 2)
Mouth Neoplasms (Phase 3)
Mucositis (Early Phase 1)
Multiple Myeloma (Phase 1/Phase 2)
Mutation (Phase 3)
Myelodysplastic Syndromes (Phase 1)
Myeloproliferative Disorders (Phase 1)
Nasopharyngeal Carcinoma (Phase 3)
Nasopharyngeal Diseases (Phase 3)
Nasopharyngeal Neoplasms (Phase 3)
Nausea (Phase 2)
Neoadjuvant Therapy (Phase 4)
Neoplasm Metastasis (Phase 4)
Neoplasm Recurrence, Local (Phase 3)
Neoplasms ()
Neoplasms, Basal Cell (Phase 4)
Neoplasms, Germ Cell and Embryonal (Phase 2)
Neoplasms, Second Primary (Phase 3)
Neoplasms, Squamous Cell (Phase 4)
Neoplastic Cells, Circulating (Phase 3)
Neoplastic Syndromes, Hereditary (Phase 2/Phase 3)
Nerve Sheath Neoplasms (Phase 3)
Neuroblastoma (Phase 1)
Neuroendocrine Tumors (Phase 4)
Neutropenia (Phase 3)
Nose Neoplasms (Phase 2)
Organ Transplantation (Phase 3)
Oropharyngeal Neoplasms (Phase 4)
Ovarian Neoplasms (Phase 2)
Oxaliplatin (Phase 2/Phase 3)
Pain (Phase 1/Phase 2)
Pancreatic Intraductal Neoplasms (Phase 3)
Pancreatic Neoplasms (Phase 4)
Papilloma, Inverted (Phase 1)
Papillomaviridae (Phase 2)
Papillomavirus Infections (Phase 3)
Paranasal Sinus Neoplasms (Phase 3)
Pathology (Phase 2/Phase 3)
Pediatrics (Phase 3)
Peripheral Nervous System Diseases (Phase 2/Phase 3)
Peritoneal Neoplasms (Phase 3)
Pharmacokinetics (Phase 2)
Pharyngeal Neoplasms (Phase 3)
Photosensitivity Disorders (Phase 4)
Postoperative Complications (Phase 4)
Precancerous Conditions (Phase 1)
Primary Myelofibrosis (Phase 1)
Progression-Free Survival (Phase 2)
Prostatic Neoplasms (Phase 1)
Proto-Oncogene Proteins B-raf (Phase 2)
Proto-Oncogene Proteins p21(ras) (Phase 1/Phase 2)
Pterygium (Phase 4)
Quality of Life (Phase 3)
Radiation (Phase 3)
Radiation Oncology (Phase 2)
Radiotherapy (Phase 2/Phase 3)
ras Proteins (Phase 3)
Receptors, Tumor Necrosis Factor, Type I (Phase 2/Phase 3)
Rectal Neoplasms (Phase 4)
Recurrence (Phase 3)
Retinal Diseases (Phase 3)
Salivary Gland Neoplasms (Phase 3)
Sarcoma (Phase 2)
Seminoma (Phase 2)
Sepsis (Phase 3)
Skin Diseases (Phase 4)
Skin Neoplasms (Phase 4)
Small Cell Lung Carcinoma (Phase 2)
Squamous Cell Carcinoma of Head and Neck (Phase 4)
Squamous Intraepithelial Lesions (Phase 3)
Stomach Neoplasms (Phase 4)
Survival (Phase 4)
Testicular Neoplasms (Phase 2)
Thymidylate Synthase (Phase 2)
Tongue Neoplasms (Phase 3)
Trabeculectomy (Phase 4)
Triple Negative Breast Neoplasms (Phase 2)
Ureteral Neoplasms (Phase 2)
Urethral Neoplasms (Phase 2)
Urinary Bladder Neoplasms (Phase 3)
Uterine Cervical Dysplasia (Phase 3)
Uterine Cervical Neoplasms (Phase 3)
Uterine Neoplasms (Phase 2)
Vitiligo (Phase 4)
Vitreoretinopathy, Proliferative (Phase 3)
Warts (Phase 4)
Wound Healing (Phase 4)
Yang Deficiency (Phase 2)
Yin Deficiency (Phase 2)
Zollinger-Ellison Syndrome (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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