Related MeSH Hierarchy (8)
Diseases [C] » Neoplasms [C04] » Neoplasms by Site » Digestive System Neoplasms » Gastrointestinal Neoplasms » Intestinal Neoplasms » Colorectal Neoplasms » Colorectal Neoplasms, Hereditary Nonpolyposis
Diseases [C] » Neoplasms [C04] » Neoplastic Syndromes, Hereditary » Colorectal Neoplasms, Hereditary Nonpolyposis
Diseases [C] » Digestive System Diseases [C06] » Digestive System Neoplasms » Gastrointestinal Neoplasms » Intestinal Neoplasms » Colorectal Neoplasms » Colorectal Neoplasms, Hereditary Nonpolyposis
Diseases [C] » Digestive System Diseases [C06] » Gastrointestinal Diseases » Gastrointestinal Neoplasms » Intestinal Neoplasms » Colorectal Neoplasms » Colorectal Neoplasms, Hereditary Nonpolyposis
Diseases [C] » Digestive System Diseases [C06] » Gastrointestinal Diseases » Intestinal Diseases » Colonic Diseases » Colorectal Neoplasms » Colorectal Neoplasms, Hereditary Nonpolyposis
Diseases [C] » Digestive System Diseases [C06] » Gastrointestinal Diseases » Intestinal Diseases » Intestinal Neoplasms » Colorectal Neoplasms » Colorectal Neoplasms, Hereditary Nonpolyposis
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Neoplastic Syndromes, Hereditary » Colorectal Neoplasms, Hereditary Nonpolyposis
Diseases [C] » Nutritional and Metabolic Diseases [C18] » Metabolic Diseases » DNA Repair-Deficiency Disorders » Colorectal Neoplasms, Hereditary Nonpolyposis
Description
A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer. MeSH
Hierarchy View
Subtype Terms (1)
Phase 2 Indicated Drugs (6)
Phase 1 Indicated Drugs (3)
Other Experimental Indicated Drugs (1)
Organization Involved with Phase 3 Indications (5)
Organization Involved with Phase 2 Indications (5)
Organization Involved with Phase 1 Indications (4)
Hierarchy Tree View
UMLS Data
YOU AGREE THAT THE INFORMATION PROVIDED ON THIS WEBSITE IS PROVIDED “AS IS”, WITHOUT ANY WARRANTY OF ANY KIND, EXPRESSED OR IMPLIED, INCLUDING WITHOUT LIMITATION WARRANTIES OF MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PURPOSE, OR NON-INFRINGEMENT OF ANY THIRD-PARTY PATENT, COPYRIGHT, OR ANY OTHER THIRD-PARTY RIGHT. IN NO EVENT SHALL THE CREATORS OF THE WEBSITE OR WASHINGTON UNIVERSITY BE LIABLE FOR ANY DIRECT, INDIRECT, SPECIAL, OR CONSEQUENTIAL DAMAGES ARISING OUT OF OR IN ANY WAY CONNECTED WITH THE WEBSITE, THE USE OF THE WEBSITE, OR THIS AGREEMENT, WHETHER IN BREACH OF CONTRACT, TORT OR OTHERWISE, EVEN IF SUCH PARTY IS ADVISED OF THE POSSIBILITY OF SUCH DAMAGES.
