Trial | NCT01666587  Report issue

Title

Ischemia Reperfusion: Prostaglandins and Antioxidants
The Role of Prostaglandin and Anti-oxidant Availability on Recovery From Forearm Ischemia-reperfusion Injury in Humans

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    12
The purposes of this study are two-fold. The first purpose is to determine the effect of taking vitamins on the recovery of an artery (blood vessel) following an induced temporary injury. The second purpose is to determine whether a specific vasodilator is less abundant after the injury and whether this contributes to increased constriction or after the injury. Finally, does vitamin consumption have an effect on the recovery from the injury if one of the substances in the blood that causes vessels to enlarge (dilate) is stopped?
Study Started
Aug 31
2012
Primary Completion
Apr 30
2013
Study Completion
Aug 31
2013
Last Update
May 12
2017

Dietary Supplement Antioxidant

Drug Prostaglandin inhibitor (Ibuprophen)

  • Other names: ibuprofen

control No Intervention

Control trial to determine the impact of the ischemic injury on vascular function without intervention

Antioxidant load Experimental

Trial to determine the impact of an antioxidant load before the ischemic injury on vascular function recovery

Prostaglandin inhibition Experimental

Trial to determine the impact of a non-selective prostaglandin inhibitor before the ischemic injury on vascular function recovery

Combined Experimental

Trial to determine the impact of an antioxidant load and prostaglandin inhibitor before the ischemic injury on vascular function recovery

Criteria 

Inclusion Criteria:

Healthy males
Healthy females

Exclusion Criteria:

Smokers
Cardiovascular disease
Peripheral vascular disease
Neurological deficits
Diabetes Type I or II
Pregnant women
Adverse reactions to Ibuprofen
No Results Posted