Active Ingredient History
Thioctic acid also known as alpha-lipoic acid is a dietary supplement, which is a common ingredient in OTC (over-the-counter) multivitamin formulas and anti-aging supplements. Thioctic acid exists in both R- and S-enantiomeric forms, however, only R-form is essential as a cofactor in biological systems (the acid is coupled via an amide linkage to a lysine of several multienzyme complexes, such as the pyruvate dehydrogenase complex, the alpha-ketoglutarate dehydrogenase complex, the glycine cleavage system and the branched-chain oxo acid dehydrogenase complex). Most commercially available thioctic acid supplements are a mixture of both R and S enantiomers or R-form alone. Several studies have shown that the acid has beneficial effect on diabetes complications, cancer, glaucome, liver disease, etc. The mechanisms of thioctic acid is related to its antioxidant properties, metal chelator properties, however, those mechanisms need futher confirmation. NCATS
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Abortion, Spontaneous (Phase 4)
Acquired Immunodeficiency Syndrome (Phase 2)
Acute Kidney Injury (Phase 4)
Adrenoleukodystrophy (Phase 2)
Aging (Phase 1/Phase 2)
Alzheimer Disease (Phase 1/Phase 2)
Anemia, Sickle Cell (Phase 2)
Antioxidants (Phase 1)
Atherosclerosis (Phase 2/Phase 3)
Autonomic Nervous System Diseases (Phase 4)
Benign Paroxysmal Positional Vertigo (Phase 1)
Bipolar Disorder (Phase 2)
Burning Mouth Syndrome (Phase 4)
Cardiovascular Diseases (Phase 2/Phase 3)
Carpal Tunnel Syndrome (Phase 4)
Clomiphene (Phase 2)
Cognition (Phase 1/Phase 2)
Cognition Disorders (Phase 2)
Coronary Artery Disease (Phase 4)
COVID-19 (Early Phase 1)
Cystic Fibrosis (Phase 2)
Cystinuria (Phase 2)
Dementia (Phase 1/Phase 2)
Diabetes Mellitus (Phase 4)
Diabetes Mellitus, Type 2 (Phase 4)
Diabetic Neuropathies (Phase 4)
Diabetic Retinopathy (Phase 1/Phase 2)
Endothelium (Phase 4)
Glaucoma, Open-Angle (Phase 1)
Healthy Volunteers (Phase 1)
Heart Diseases (Phase 4)
Heart Failure (Phase 4)
Hematoma (Phase 4)
HIV (Phase 1/Phase 2)
HIV Infections (Phase 2)
Hypercholesterolemia (Phase 2)
Hyperlipidemias (Phase 1/Phase 2)
Hypertension (Phase 1/Phase 2)
Hypertension, Pulmonary (Phase 1)
Hypertrophy, Left Ventricular (Phase 4)
Infertility, Female (Phase 4)
Inflammation (Phase 1/Phase 2)
Insulin Resistance (Phase 2)
Ischemic Stroke (Phase 3)
Kidney Failure, Chronic (Phase 4)
Liver Diseases (Phase 4)
Lumbar Vertebrae (Phase 2)
Macular Degeneration (Phase 1/Phase 2)
Macular Edema (Phase 3)
Metabolic Syndrome (Phase 2)
Migraine Disorders (Phase 4)
Mucositis (Phase 4)
Multiple Sclerosis (Phase 2)
Multiple Sclerosis, Chronic Progressive (Phase 2/Phase 3)
Neoplasms (Phase 3)
Non-alcoholic Fatty Liver Disease (Phase 4)
Obesity (Phase 2/Phase 3)
Optic Neuritis (Phase 1)
Oral Submucous Fibrosis (Phase 3)
Ototoxicity (Phase 2/Phase 3)
Oxidative Stress (Phase 4)
Peripheral Nervous System Diseases (Phase 1/Phase 2)
Plasma (Phase 4)
Polycystic Ovary Syndrome (Phase 2)
Postoperative Complications (Phase 4)
Prediabetic State (Phase 4)
Pregnancy (Phase 4)
Pregnancy Complications (Phase 4)
Presbyopia (Phase 2)
Primary Ovarian Insufficiency (Phase 2)
Pulmonary Disease, Chronic Obstructive (Phase 1)
Renal Insufficiency, Chronic (Phase 2)
Schizophrenia (Phase 2/Phase 3)
Sepsis (Phase 2/Phase 3)
Sleep Apnea, Obstructive (Phase 2/Phase 3)
Squamous Cell Carcinoma of Head and Neck (Phase 1)
Stomatitis (Phase 4)
Supranuclear Palsy, Progressive (Phase 1/Phase 2)
Takotsubo Cardiomyopathy (Phase 4)
Thyroid Gland (Phase 2)
Vitamin D (Phase 1)
| Trial | Phase | Start Date | Organizations | Indications |
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