Related MeSH Hierarchy (4)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Scleroproteins » Extracellular Matrix Proteins » ADAMTS Proteins » ADAMTS13 Protein
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Hydrolases » Peptide Hydrolases » Metalloproteases » Metalloendopeptidases » ADAM Proteins » ADAMTS Proteins » ADAMTS13 Protein
Chemicals and Drugs [D] » Carbohydrates [D09] » Glycoconjugates » Glycoproteins » ADAM Proteins » ADAMTS Proteins » ADAMTS13 Protein
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Glycoproteins » ADAM Proteins » ADAMTS Proteins » ADAMTS13 Protein
Description
An ADAMTS protease that contains eight thrombospondin (TS) motifs. It cleaves VON WILLEBRAND FACTOR to control vWF-mediated THROMBOSIS. Mutations in the ADAMTS13 gene have been identified in familial cases of PURPURA, THROMBOTIC THROMBOCYTOPENIC and defects in ADAMTS13 activity are associated with MYOCARDIAL INFARCTION; BRAIN ISCHEMIA; PRE-ECLAMPSIA; and MALARIA. MeSH
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