Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Scleroproteins » Extracellular Matrix Proteins
Description
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ). MeSH
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Subtype Terms (20)
Activated-Leukocyte Cell Adhesion Molecule
Cartilage Oligomeric Matrix Protein
CCN Intercellular Signaling Proteins
Collagen
11 drugs (5 approved, 6 experimental)
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