Active Ingredient History

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Digoxin, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Digoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium. The sodium calcium exchanger (NCX) in turn tries to extrude the sodium and in so doing, pumps in more calcium. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Digoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.   NCATS

  • SMILES: C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@H]2[C@@H](O)C[C@H](O[C@H]3[C@@H](O)C[C@H](O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4)O[C@@H]3C)O[C@@H]2C
  • InChIKey: LTMHDMANZUZIPE-PUGKRICDSA-N
  • Mol. Mass: 780.9385
  • ALogP: 2.22
  • ChEMBL Molecules:
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Drug Pricing (per unit)

Australia

$0.0141 - $11.7070

United States

$0.1420 - $129.4190
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

12beta-hydroxydigitoxin | 12β-hydroxydigitoxin | 4-[(3s,5r,8r,9s,10s,12r,13s,14s)-3-[(2s,4s,5r,6r)-5-[(2s,4s,5r,6r)-5-[(2s,4s,5r,6r)-4,5-dihydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5h-furan-2-one | acetyldigoxin | beta acetyldigoxin | beta-acetyldigoxin | cardiogoxin | digamex | digazolan | digossina | digoxin | digoxina | digoxine | digoxin pediatric | digoxinum | lanadicor | lanoxicaps | lanoxin | lanoxin-125 | lanoxin pediatric | lanoxin-pg | novodigal | vanoxin

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