Trial | NCT02441530  Report issue

Title

Effectiveness of Vitamin D in Primary Dysmenorrhoea
Vitamin D in the Treatment of Primary Dysmenorrhoea: A Prospective Randomised Controlled Trial

  • Phase

    Phase 3

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    143
Vitamin D in the treatment of primary dysmenorrhoea. Design:Randomised controlled trial. Setting:In a university hospital. Population: 142 women aged 16-35 years. Methods: Patients were treated with 667 unit of vitamin D once a day, 200 unit of vitamin E once a day or 400 mg ibuprofen twice a day,2 days before the date of menstruation and continued through the first 3 days, for 2 months. Main outcome measures: Pain score. Results: Mean VAS of vitamin D group was 4,91, was 6,54 in the vitamin E group and was 4,02 in the ibuprofen group Conclusion:Vitamin D and vitamin E are effective in relieving the pain,but the effect of vitamin D are more prominent
An excessive uterine production of prostaglandins is the pathogenic trigger of dysmenorrhoea. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the currently accepted drugs for the management of this disorder. The capacity for synthesizing vitamin D and the presence of vitamin D receptor in human cycling endometrium have also been demonstrated. Because vitamin D reduces the synthesis of prostaglandins, a beneficial effect of vitamin D for the uterus is possible.Vitamin E inhibits the release of arachidonic acid and the conversion of arachidonic acid to prostaglandin via an action on the enzymes phospholipase A2 and cyclooxygenase.
Study Started
Nov 30
2012
Primary Completion
Jan 31
2013
Study Completion
Oct 31
2013
Last Update
May 12
2015
Estimate

Dietary Supplement Vitamin D

  • Other names: Devit-3 damla barcod number 8699525590435 ,DEVA Holding AŞ

Dietary Supplement Vitamin E

  • Other names: Evicap d-alfa-Tokoferol, KOÇAK Farma

Drug Ibuprofen

  • Other names: profen Dinçtaş İlaç

vitamin D Experimental

667 unit of vitamin D once a day ,two days before the expected date of menstruation and continued through the first three days of bleeding.

vitamin E Experimental

200 unit of vitamin E once a day ,two days before the expected date of menstruation and continued through the first three days of bleeding.

ibuprofen Experimental

400 mg ibuprofen twice a day, two days before the expected date of menstruation and continued through the first three days of bleeding.

Criteria 

Inclusion Criteria:

Women had regular menstrual cycles lasted 21 to 35 days, with menstruation lasting 3 to 7 days;
Women had to be in good health and taking no medications including calcium, magnesium, vitamin D and oral contraceptives.
Women had not a previous history of gynaecological disease, and a normal pelvic examination were eligible.

Exclusion Criteria:

1) Previous and current use of intrauterine contraceptive devices within the 6 months to enrollment was not permitted
No Results Posted