Title
Evaluation of Techniques for Scaling and Root Planing and One Stage Full Mouth Disinfection
Clinical and Microbiological Evaluation of Techniques for Scaling and Root Planing Per Quadrant and One Stage Full Mouth Disinfection Associated With Azithromycin or Chlorhexidine: Randomized Controlled Trial
Phase
N/ALead Sponsor
Centro Universitario de LavrasStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Periodontal Disease Chronic PeriodontitisIntervention/Treatment
zinc dichloride azithromycin chlorhexidine ...Study Participants
77Evaluate and compare the effectiveness in a clinical and microbial perspective one stage full-mouth disinfection technique in relation to scaling and root planing per quadrant associated with chlorhexidine or azithromycin.
Seventy -seven systemically healthy subjects with chronic periodontitis were randomly included in 6 different predefined groups. The following periodontal parameters were evaluated: probing depth , clinical attachment level , plaque index, gingival index and percentage of areas affected by periodontal disease. Microbiologically were evaluated the bacterial load and specific load of five bacterias: The quantification of the bacteria was performed by real-time Polymerase Chain Reaction . The clinical and microbial baseline evaluations were performed ( periodontal pre- therapy) , 90 and 180 days after treatment.
Scaling procedures were performed per quadrant (30 min. per quadrant) at weekly intervals between sessions;
Procedures for scaling and root planing were performed in a single stage (24 hours) divided into two sessions (60 min per session) on two consecutive days
application of chlorhexidine (CX) (1%) gel in pockets after scaling, brushing tongue for 1 min. with CX (1%) gel and mouthwash at the beginning and end of each session with CX 0.2% for 30 seconds (with the form of a gargle in the last 10 seconds)
Home use fo CX 0.2% for 60 consecutive days after the end of the first session of scaling.
Azithromycin (500 mg) once daily for 3 consecutive days.
n = 10: Procedures for scaling and root planing were performed in a single stage (24 hours) divided into two sessions (60 min per session) on two consecutive days
n = 15: Same as FMD with the inclusion of chlorhexidine in office (application of chlorhexidine (CX) (1%) gel in pockets after scaling, brushing tongue for 1 min. with CX (1%) gel and mouthwash at the beginning and end of each session with CX 0.2% for 30 seconds (with the form of a gargle in the last 10 seconds)). In addition, use was made of homemade CX 0.2% for 60 days after the scaling in a single phase.
n = 15: Same as with the FMD include the use of azithromycin (500 mg) once daily for 3 consecutive days. Medication was started the same day as the end of the scaling.
(n = 13): scaling procedures were performed per quadrant (30 min. per quadrant) at weekly intervals between sessions;
n = 11: Same as scaling and root planing group (SRP) with inclusion of the use of azithromycin (500 mg) once daily for 3 consecutive days. Medication was started the same day as the end of the last scaling hemi-arch;
n = 13 : Same as group scaling and root planing (SRP) with the inclusion of home use of CX 0.2% for 60 consecutive days after the end of the first session of scaling
Inclusion Criteria: Diagnosis of slight-moderate chronic periodontitis Exclusion Criteria: Those who were making regular use of antibiotics or anti-inflammatory drugs or had done up to three months before the beginning of the study; those who were making regular use (twice a day) of oral rinses with chlorhexidine or essential oils or have made regular use within three months prior to study entry; individuals with a history of sensitivity to chlorhexidine or azithromycin; subjects undergoing periodontal therapy include dental scaling procedures in the 12 months preceding the start of the study; subjects with impaired bifurcation or trifurcation class III; who required antibiotic prophylaxis for conducting clinical periodontal examination subjects with removable partial dentures and removable or fixed orthodontic appliance.
