Official Title
Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis
Phase
Phase 1Lead Sponsor
University of CopenhagenStudy Type
InterventionalStatus
Unknown statusIndication/Condition
Osteoarthritis of the KneeIntervention/Treatment
ibuprofen glucosamine ...Study Participants
36The investigators will investigate the effect of glucosamine or ibuprofen combined with 12 weeks of muscle strength-training in patients with knee-osteoarthritis.
The investigators would like to elucidate whether treatment with glucosamine or NSAID interact with the effects of exercise in osteoarthritis patients.
Subjects are administered glucosamine-sulphate tablets of 500 mg * 3 daily, while they are performing a strength-training program with both legs (*3 weekly) for 12 weeks.
Subjects are administered 600 mg * 2 daily, while they are performing a strength-training program with both legs (*3 weekly) for 12 weeks
Subjects are administered placebo tablets, while they are performing a strength-training program (*3 weekly) with both legs for 12 weeks
Inclusion Criteria: Age 50 to 70 years Bilateral tibiofemoral osteoarthritis of the knee on x-ray American College of Rheumatology (ACR) clinical classification criteria Exclusion Criteria: Severe health problems such as cardiovascular disease, active cancer, diabetes, kidney or liver diseases Excess alcohol use (> 21 alcoholic drinks per week) Severe overweight (BMI > 35) History of injury or operation in the knee, planned knee-joint replacement, other rheumatologic diseases, previous gastric ulcer, allergy to the contents of ibuprofen or glucosamine, regular strength training prior to the inclusion
