Trial | NCT00631514  Report issue

Title

Interaction Between Antihypertensives and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Relevance of the Interaction Between Antihypertensive and Antirheumatic Drugs in a Family Practice

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    88
NSAIDs may increase blood pressure and blunt the effects of many antihypertensives. Members of these drug classes differ in their propensity to such an interaction.
To compare prospectively the effects of piroxicam, ibuprofen and acetaminophen on blood pressure control in hypertensive patients with osteoarthritis.
Study Started
Jan 31
2005
Primary Completion
Sep 30
2006
Study Completion
Sep 30
2006
Last Update
Mar 10
2008
Estimate

Drug acetaminophen

acetaminophen 1000 mg t.i.d. per os ibuprofen 400-600 mg t.i.d. per os piroxicam 10-20 mg o.d. per os

  • Other names: paracetamol

Drug ibuprofen

acetaminophen 1000 mg t.i.d. per os ibuprofen 400-600 mg t.i.d. per os piroxicam 10-20 mg o.d. per os

Drug piroxicam

acetaminophen 1000 mg t.i.d. per os ibuprofen 400-600 mg t.i.d. per os piroxicam 10-20 mg o.d. per os

1 No Intervention

Hypertensive persons taking either lisinopril/hydrochlorothiazide fixed combination or amlodipine all the time.

2 Experimental

Intervention: NSAID. Hypertensives with osteoarthritis taking already amlodipine (5-10 mg o.d. per os) were randomized to the following drug interventions: to take either acetaminophen (1000 mg t.i.d. per os), piroxicam (10-20 mg o.d. per os) or ibuprofen (400-600 mg t.i.d. per os) for 1 month

3 Experimental

Hypertensives with osteoarthritis taking already lisinopril/hydrochlorothiazide (20/12.5 mg o.d. per os), were sequentially randomized to the following drug interventions: acetaminophen (1000 mg t.i.d.), ibuprofen (400-600 mg t.i.d.) or piroxicam (10-20 mg o.d.), for 1 month each

Criteria 

Inclusion Criteria:

Treated hypertensives of either gender aged between 55 and 76 years
About 50% with concomitant osteoarthritis of the hip or knee

Exclusion Criteria:

Normotensive persons or untreated hypertensives
Individuals outside the age limits
General exclusion criteria (e.g. uncooperative persons, advanced malignancies, participants in other studies)
No Results Posted