Title
Spinal Anesthesia With Articaine and Bupivacaine for Outpatient Lower Limb Surgery
Spinal Anesthesia With 5% Articaine and 0.5% Bupivacaine for Outpatient Lower Limb Surgery. A Double-Blind Randomised Clinical Trial
Phase
Phase 3Lead Sponsor
Reinier de Graaf GroepStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Spinal AnesthesiaIntervention/Treatment
levobupivacaine articaine ...Study Participants
80The purpose of the trial is to compare two local anesthetics, articaine and bupivacaine for outpatient lower limb surgery. Onset and recovery times of sensory and motor blockade will be compared.
The purpose of the trial is to compare two local anesthetics, articaine and bupivacaine for outpatient lower limb surgery.
Faster onset and shorter elimination time favours a short-acting local anaesthetic for spinal anesthesia for out-patient lower limb surgery, e.g. knee arthroscopy, foot and varices surgery. Patients will recover faster and less complications will be expected.
Articaine is said to act faster and shorter than a low dose of bupivacaine. There are not enough data available to establish that articaine is as safe as and more effective by outpatient lower limb surgery than bupivacaine.
Spinal anesthesia with articaine will be compared to spinal anesthesia with bupivacaine in a randomized double blind clinical trial.
Endpoints are:
onset of sensory and motor block
maximum spread of sensory level
recovery from sensory and motor block
time to micturition
complications
Inclusion Criteria: Age between 18 and 70 years Patients planned for an outpatient lower limb surgery Procedure under spinal anesthesia Informed consent Exclusion Criteria: Contra-indications spinal anesthesia History of allergic reactions on amide-type local anesthetics Length < 1.60 m or > 1.90 m BMI < 18.5 kg/m2 or > 35 kg/m2 Pregnancy
