Active Ingredient History
Levobupivacaine (CHIROCAINE®) is a (S)-enantiomer of bupivacaine and it is related chemically and pharmacologically to the amino amide class of local anesthetics. Local anesthetics block the generation and the conduction of nerve impulses by increasing the threshold for electrical excitation in the nerve, by slowing propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of affected nerve fibers. Clinically, the order of loss of nerve function is as follows: 1) pain, 2) temperature, 3) touch, 4) proprioception and 5) skeletal muscle tone. Levobupivacaine (CHIROCAINE®) is a safer alternative for regional anesthesia than bupivacaine. It demonstrated less affinity and strength of depressant effects onto myocardial and central nervous vital centers in pharmacodynamic studies, and a superior pharmacokinetic profile. NCATS
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Abdominal Neoplasms (Phase 4)
Abdominal Pain (Phase 2/Phase 3)
Abdominoplasty (Phase 4)
Acute Pain (Phase 4)
Alzheimer Disease (Phase 3)
Ambulatory Surgical Procedures (Phase 4)
Amputation Stumps (Phase 4)
Analgesia (Phase 4)
Analgesia, Epidural (Phase 4)
Analgesia, Patient-Controlled (Phase 4)
Analgesics, Opioid (Phase 4)
Anesthesia (Phase 4)
Anesthesia and Analgesia (Phase 4)
Anesthesia, Conduction (Phase 4)
Anesthesia, Epidural (Phase 4)
Anesthesia, General (Phase 4)
Anesthesia, Local (Phase 4)
Anesthesia, Obstetrical (Phase 4)
Anesthesia, Spinal (Phase 4)
Anesthetics, Local (Phase 4)
Ankle Fractures (Phase 3)
Ankle Injuries (Phase 4)
Anterior Cruciate Ligament Injuries (Phase 4)
Aortic Coarctation (Phase 1)
Aortic Valve Disease (Phase 4)
Appendicitis (Phase 2)
Arterial Occlusive Diseases (Phase 4)
Arthritis (Phase 4)
Arthrodesis (Phase 4)
Arthropathy, Neurogenic (Phase 4)
Arthroplasty (Phase 4)
Arthroplasty, Replacement, Hip (Phase 4)
Arthroplasty, Replacement, Knee (Phase 4)
Arthroscopy (Phase 4)
Back Pain (Phase 3)
Balanitis (Phase 1)
Bariatric Surgery (Phase 4)
Blepharoptosis (Phase 2/Phase 3)
Blood Coagulation (Phase 2)
Blood Loss, Surgical (Phase 4)
Brachial Plexus Block (Phase 4)
Bradycardia (Phase 4)
Brain Neoplasms (Phase 4)
Breakthrough Pain (Phase 4)
Breast (Phase 4)
Breast Diseases (Phase 4)
Breast Neoplasms (Phase 4)
Breech Presentation (Phase 3)
Bunion (Phase 3)
Bupivacaine (Phase 4)
Bursitis (Phase 4)
Carcinoma, Renal Cell (Phase 2/Phase 3)
Cardiac Output (Phase 4)
Carpal Tunnel Syndrome (Phase 4)
Catheters (Phase 3)
Cervical Intraepithelial Neoplasia (Phase 4)
Cervix Uteri (Phase 4)
Cesarean Section (Phase 4)
Cholecystectomy, Laparoscopic (Phase 4)
Cholecystolithiasis (Phase 4)
Cholelithiasis (Phase 4)
Cholesteatoma (Phase 2)
Chronic Pain (Phase 4)
Cochlear Implants (Phase 2)
Colonic Neoplasms (Phase 4)
Colorectal Surgery (Phase 4)
Colostomy (Phase 4)
Conscious Sedation (Phase 4)
Constipation (Phase 4)
Contracture (Phase 2)
Coronary Artery Bypass (Phase 4)
Coronary Artery Disease (Phase 2)
Coronary Vasospasm (Phase 2)
Cough (Phase 3)
Critical Illness (Phase 3)
Delivery of Health Care (Phase 4)
Dexmedetomidine (Phase 4)
Diverticulitis (Phase 4)
Diverticulitis, Colonic (Phase 4)
Drugs, Investigational (Phase 4)
Dyspareunia (Phase 4)
Early Ambulation (Phase 4)
Eczema (Phase 3)
Emergency Medicine (Phase 4)
Endometrial Neoplasms (Phase 4)
Episiotomy (Phase 4)
Esotropia (Phase 2/Phase 3)
Exotropia (Phase 2/Phase 3)
Facial Pain (Phase 4)
Fascia (Phase 4)
Fasciitis, Plantar (Phase 2/Phase 3)
Femoral Fractures (Phase 4)
Femoral Neck Fractures (Phase 4)
Fentanyl (Phase 4)
Finger Injuries (Phase 4)
Flushing (Phase 2)
Forearm Injuries (Phase 4)
Fractures, Bone (Phase 4)
Gallbladder Diseases (Phase 4)
Gallstones (Phase 4)
General Surgery (Phase 4)
Genital Neoplasms, Female (Phase 3)
Graves Disease (Phase 2/Phase 3)
Hallux Valgus (Phase 4)
Hand Injuries (Phase 4)
Hand Strength (Phase 4)
Headache (Phase 4)
Head and Neck Neoplasms (Phase 4)
Healthy Volunteers (Phase 1/Phase 2)
Heart Diseases (Phase 4)
Hemodynamics (Phase 4)
Hemorrhoids (Phase 4)
Hernia (Phase 4)
Hernia, Inguinal (Phase 4)
Hernia, Umbilical (Phase 2/Phase 3)
Hernia, Ventral (Phase 4)
Herniorrhaphy (Phase 3)
Hip Fractures (Phase 4)
Hip Injuries (Phase 4)
HIV Infections (Phase 1)
Hot Flashes (Phase 2)
Humans (Phase 4)
Hypertension (Phase 4)
Hypnotics and Sedatives (Phase 4)
Hypospadias (Phase 4)
Hypotension (Phase 4)
Hysterectomy (Phase 4)
Ileus (Phase 4)
Immune System Diseases (Phase 4)
Inflammation (Phase 4)
Infratentorial Neoplasms (Phase 2)
Infusion Pumps (Phase 4)
Intervertebral Disc Displacement (Phase 4)
Intestinal Diseases (Phase 4)
Intestinal Pseudo-Obstruction (Phase 4)
Intraoperative Complications (Phase 3)
Joint Diseases (Phase 1)
Ketamine (Phase 4)
Kidney Calculi (Phase 3)
Kidney Failure, Chronic (Phase 3)
Knee (Phase 4)
Knee Injuries (Phase 4)
Labor, Obstetric (Phase 4)
Labor Pain (Phase 4)
Laparoscopy (Phase 3)
Leg Injuries (Phase 4)
Levobupivacaine (Phase 4)
Ligaments, Articular (Phase 4)
Liver Diseases (Phase 1)
Low Back Pain (Phase 4)
Lumbar Vertebrae (Phase 4)
Lung Diseases (Phase 4)
Lung Neoplasms (Phase 4)
Lymph Node Excision (Phase 4)
Mammaplasty (Phase 4)
Mastectomy (Phase 4)
Mastectomy, Modified Radical (Phase 4)
Mastodynia (Phase 4)
Mastoidectomy (Phase 2)
Melanoma (Phase 1)
Meniscectomy (Phase 4)
Meniscus (Phase 4)
Migraine Disorders (Phase 4)
Morphine (Phase 4)
Mucositis (Phase 2)
Musculoskeletal Diseases (Phase 4)
Musculoskeletal Pain (Phase 4)
Myocardial Ischemia (Phase 4)
Nasal Obstruction (Phase 3)
Nasal Surgical Procedures (Phase 4)
Nausea (Phase 4)
Neoplasm Metastasis (Phase 3)
Neoplasms (Phase 3)
Nephrolithotomy, Percutaneous (Phase 4)
Nerve Block (Phase 4)
Nerve Fibers (Phase 4)
Neuralgia (Phase 4)
Neuralgia, Postherpetic (Phase 2)
Neuroma (Phase 4)
Neuromuscular Blockade (Phase 4)
Neuromuscular Junction (Phase 4)
Obesity (Phase 4)
Obesity, Morbid (Phase 2/Phase 3)
Obstetric Labor Complications (Phase 3)
Opioid-Related Disorders (Phase 2/Phase 3)
Orthopedic Procedures (Phase 4)
Osteoarthritis (Phase 4)
Osteoarthritis, Hip (Phase 4)
Osteoarthritis, Knee (Phase 4)
Outpatients (Phase 4)
Pain ()
Pain, Intractable (Phase 4)
Pain Management (Phase 4)
Pain, Postoperative (Phase 4)
Pancreatic Neoplasms (Phase 1)
Pancreatitis (Phase 2/Phase 3)
Pancreatitis, Chronic (Phase 3)
Paraphimosis (Phase 1)
Pelvic Organ Prolapse (Phase 4)
Periodontitis (Phase 2)
Personal Satisfaction (Phase 4)
Pharmaceutical Preparations (Phase 4)
Pharmacokinetics (Phase 4)
Phimosis (Phase 1)
Phytotherapy (Phase 4)
Pneumonia (Phase 3)
Post-Dural Puncture Headache (Early Phase 1)
Postoperative Cognitive Complications (Phase 4)
Postoperative Complications (Phase 4)
Postoperative Hemorrhage (Phase 4)
Postoperative Nausea and Vomiting (Phase 4)
Pre-Eclampsia (Phase 4)
Pregnancy (Phase 4)
Pregnancy Complications (Phase 3)
Pregnant Women (Phase 3)
Prostatectomy (Phase 4)
Prostatic Neoplasms (Phase 1/Phase 2)
Pruritus (Phase 4)
Quality of Life (Phase 4)
Radiculopathy (Phase 4)
Rectal Diseases (Phase 4)
Rectal Fistula (Phase 4)
Rectal Neoplasms (Phase 4)
Respiratory Paralysis (Phase 3)
Retinal Detachment (Phase 4)
Retinoschisis (Phase 4)
Rhinitis (Phase 3)
Rhinoplasty (Phase 3)
Rib Fractures (Phase 4)
Rotator Cuff Injuries (Phase 4)
Sciatic Neuropathy (Phase 4)
Scoliosis (Phase 4)
Shoulder (Phase 4)
Shoulder Injuries (Phase 4)
Shoulder Pain (Phase 4)
Sleep Apnea Syndromes (Phase 4)
Spinal Fusion (Phase 3)
Spinal Injuries (Phase 4)
Strabismus (Phase 2/Phase 3)
Supranuclear Palsy, Progressive (Phase 4)
Surgical Procedures, Operative (Phase 4)
Tacrine (Phase 4)
Tendon Injuries (Phase 3)
Therapeutics (Phase 2/Phase 3)
Thoracic Diseases (Phase 2/Phase 3)
Thoracic Injuries (Phase 2)
Thoracic Neoplasms (Phase 2/Phase 3)
Thoracic Surgery (Phase 3)
Thyroidectomy (Phase 4)
Tonsillectomy (Phase 4)
Toothache (Phase 4)
Tooth Extraction (Phase 2)
Trigger Finger Disorder (Phase 4)
Ultrasonography (Phase 4)
Urethral Diseases (Phase 4)
Urinary Bladder Neoplasms (Phase 4)
Urologic Diseases (Phase 4)
Vaginal Diseases (Phase 4)
Vasomotor System (Phase 2)
Vasoplegia (Early Phase 1)
Vasospasm, Intracranial (Phase 1)
Ventricular Dysfunction, Right (Phase 4)
Version, Fetal (Phase 4)
Vision Disorders (Phase 4)
Vitreoretinopathy, Proliferative (Phase 4)
Vomiting (Phase 4)
Wounds and Injuries (Phase 4)
Wrist Injuries (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
Feedback
Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).
Report issue
