Active Ingredient History
Articaine is a dental local anesthetic, which is the most widely used in a number of European countries and is available in many countries around the world. Articaine in combination with epinephrine under the brand name Septocaine is indicated for local, infiltrative, or conductive anesthesia in both simple and complex dental procedures. Local anesthetics block the generation and conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rising of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction velocity of the affected nerve fibers. Articaine blocks the actions on Na+ channels. Epinephrine is a vasoconstrictor added to articaine HCl to slow absorption into the general circulation and thus prolong maintenance of an active tissue concentration. NCATS
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Pain (approved 2000)
Abdominal Pain (Phase 4)
Anesthesia (Phase 4)
Anesthesia, Dental (Phase 4)
Anesthesia, Local (Phase 4)
Anesthesia, Spinal (Phase 3)
Aortic Valve Disease (Phase 4)
Behavior (Phase 1/Phase 2)
Child Behavior (Phase 3)
Cicatrix (Phase 4)
Contraception (Phase 4)
Dental Caries (Phase 3)
Dental Implantation (Phase 4)
Dental Pulp Diseases (Phase 3)
Dyspepsia (Phase 4)
Gastroscopy (Phase 4)
General Surgery (Phase 1)
Healthy Volunteers (Phase 1)
Heartburn (Phase 4)
Heart Septal Defects, Atrial (Phase 4)
Hematemesis (Phase 4)
Intrauterine Devices (Phase 4)
Mitral Valve (Phase 4)
Myxoma (Phase 4)
Opioid-Related Disorders (Phase 4)
Pain (Phase 4)
Pain, Postoperative (Phase 4)
Periapical Periodontitis (Phase 2)
Periodontitis (Phase 4)
Pharmacokinetics (Phase 4)
Pulpitis (Phase 4)
Renal Insufficiency (Early Phase 1)
Stomatognathic Diseases (Phase 3)
Tooth (Phase 4)
Tooth Abnormalities (Phase 4)
Tooth Extraction (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
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