Trial | NCT00198562  Report issue

Title

Hypertension Control Based on Home Blood Pressure
Hypertension Control Based on Home Systolic Pressure Study (HOSP Study)

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Unknown status

  • Study Participants

    2600
The aim of this trial is to study the effects of antihypertensive therapy based on home systolic blood pressure (BP) with different target levels using two classes of drugs.

The HOSP study is a multicenter, prospective, randomized, open, blinded endpoint study. The study subjects are 40-79 years old hypertensive patients. After a 4 weeks of baseline period, subjects are randomly assigned to (1) modest control group (morning home BP <140 mmHg) or (2) strict control group (morning home BP <130 mmHg), and to (a) amlodipine group or (b) losartan group. Additional antihypertensive drugs can be used if home BP is not controlled. Home BP is measured in the early morning and late evening. The participants will be followed up for 5 years.
The aim of this trial is to study the effects of antihypertensive therapy based on home systolic blood pressure (BP) with different target levels using two classes of drugs.

The HOSP study is a multicenter, prospective, randomized, open, blinded endpoint study. Inclusion criteria are 40-79 years old treated or untreated hypertensive patients without serious medical conditions. After a 4 weeks of baseline period, subjects are randomly assigned to (1) modest control group (target morning home BP <140 mmHg) or (2) strict control group (morning home BP <130 mmHg), and to (a) amlodipine group (2.5-5 mg od) or (b) losartan group (25-50 mg od). Additional antihypertensive drugs (diuretics, beta-blockers and alpha-blockers) can be used if home BP is not controlled. Home BP is measured in the early morning and late evening. Primary end point is combined cardiovascular events.The participants will be followed up for 5 years.
Study Started
Apr 30
2000
Primary Completion
Mar 31
2012
Anticipated
Study Completion
Mar 31
2012
Anticipated
Last Update
Apr 22
2008
Estimate

Drug Amlodipine, Losartan

amlodipine: 2.5-10 mg once daily for 5 years losartan: 25-100 mg once daily for 5 years

  • Other names: other antihypertensive drugs (if required)

1 Active Comparator

target morning home blood pressure (below 130 mmHg vs 130-139 mmHg)

2 Active Comparator

antihypertensive drug (amlodipine vs losartan)

Criteria 

Inclusion Criteria:

Clinical diagnosis of hypertension

Exclusion Criteria:

Severe hypertension (treated with 3 or more antihypertensive drugs)
Unable to change antihypertensive drugs to a calcium antagonist or an angiotensin antagonist
Serious medical conditions
Women who may become to be pregnant
No Results Posted