Title
D4T or Abacavir Plus Vitamin Enhancement in HIV-Infected Patients (DAVE)
Randomized, Open-Label Study of Continued Stavudine Versus Abacavir Substitution With or Without Riboflavin and Thiamine Supplementation in HIV-Infected Patients Who Have Elevated Venous Lactic Acid While on Stavudine-Based Therapy (DAVE)
Phase
Phase 2/Phase 3Lead Sponsor
University of British ColumbiaStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Acidosis, LacticIntervention/Treatment
abacavir stavudine thiamine riboflavin ...Study Participants
80The purpose of this study is to determine the best way to treat people on d4T (stavudine) with high levels of lactic acid. Switching from d4T to abacavir will be assessed. Adding riboflavin and thiamine will also be assessed.
Participants will be randomly assigned to one of four groups:
Group 1 participants will continue to take d4T as part of their antiretroviral (ARV) regimen, and will be given the vitamin supplements
Group 2 will continue to take d4T without vitamin supplements
Group 3 will switch from d4T to abacavir and receive the vitamins
Group 4 will switch from d4T to abacavir without vitamin supplements.
The study plans to involve eighty participants from Canada and Argentina for a treatment period of 16 weeks and a follow-up visit at week 24.
See Detailed Description.
See Detailed Description.
See Detailed Description.
Inclusion Criteria: Be HIV-positive Be 18 years of age or older Have a viral load equal to or below 50 copies/mL Have been on a d4T-containing multiple drug regimen (at least three agents in total) for at least six months Have been on a stable ARV regimen for the three months prior to enrollment Have a venous lactic acid measurement above 2.1 mmol/L within the three months prior to enrollment and two consecutive measurements above 2.1 but lower than 6.0 within a two-week period of screening Be willing to discontinue L-carnitine and/or coenzyme Q10 Be willing and able to provide informed consent Exclusion Criteria: Pregnancy or breastfeeding Venous lactic acid equal to or above 6.0 mmol/L Previous exposure to abacavir Virologic rebound while on a previous regimen consisting of dual or triple nucleoside reverse transcriptase inhibitors (NRTIs) Use of hydroxyurea within the three months prior to enrollment Use of metformin Any acute cardiopulmonary illness or infection New AIDS-defining illness diagnosed within four weeks of enrollment Riboflavin or thiamine supplementation above 20 mg/day within 30 days prior to enrollment
