abacavir (ziagen) Report issue

Small molecule Approved FDA Fast Track FDA Accelerated Approval FDA Priority Review FDA

Active Ingredient History

NOW
  • Now
Abacavir is a nucleoside reverse transcriptase inhibitor used for treatment of HIV infection (either alone or in combination with other antiviral drugs). It was shown that abacavir exerts its antiviral activity through its active metabolite, carbovir triphosphate. Carbovir triphosphate is a guanine analogue and a potent and selective inhibitor of viral reverse transcriptases. Upon administration, abacavir is first converted to abacavir monophosphate by ADK, then the monophosphate is deaminated to carbovir monophosphate, which is then anabolized by cellular kinases to carbovir diphosphate and then finally to carbovir triphosphate. Abacavir causes hypersensitivity reaction in patients with HLA-B*57:01 allele.   NCATS

More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: Yes

Drug Pricing (per unit)

United States

$0.4492 - $9.1703

Australia

$2.9597 - $51.7280
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Combination drugs

| |
( abacavir (ziagen), lamivudine (epivir), zidovudine (retrovir) - other name: abacavir sulfate; lamivudine; zidovudine )
1592u89 | (1s,4r)-4-(2-amino-6-(cyclopropylamino)-9h-purin-9-yl)-2-cyclopentene-1-methanol | {(1s-cis)-4-[2-amino-6-(cyclopropylamino)-9h-purin-9-yl]cyclopent-2-en-1-yl}methanol | abacavir | abacavir (as sulfate) / lamivudine / zidovudine | abacavir - lamivudine | abacavir / lamivudine | abacavir-lamivudine combination | abacavir, lamivudine drug combination | abacavir succinate | abacavir sulfate | abacavir sulfate / dolutegravir sodium / lamivudine | abacavir sulfate-lamivudine combination | abc | epzicom | lamivudine / zidovudine / abacavir sulfate | ziagen

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