Chemicals and Drugs [D] » Nucleic Acids, Nucleotides, and Nucleosides [D13] » Nucleic Acids » RNA » RNA, Untranslated » RNA, Small Untranslated » RNA, Small Interfering
Chemicals and Drugs [D] » Nucleic Acids, Nucleotides, and Nucleosides [D13] » Antisense Elements (Genetics) » RNA, Antisense » RNA, Small Interfering
Chemicals and Drugs [D] » Nucleic Acids, Nucleotides, and Nucleosides [D13] » Nucleic Acids » RNA » RNA, Antisense » RNA, Small Interfering
Description
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions. MeSH
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