Chemicals and Drugs [D] » Nucleic Acids, Nucleotides, and Nucleosides [D13] » Antisense Elements (Genetics) » RNA, Antisense » MicroRNAs
Chemicals and Drugs [D] » Nucleic Acids, Nucleotides, and Nucleosides [D13] » Nucleic Acids » RNA » RNA, Antisense » MicroRNAs
Chemicals and Drugs [D] » Nucleic Acids, Nucleotides, and Nucleosides [D13] » Nucleic Acids » RNA » RNA, Untranslated » RNA, Small Untranslated » MicroRNAs
Description
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing. MeSH
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