Related MeSH Hierarchy (4)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Carrier Proteins » Membrane Transport Proteins » Ion Pumps » Anion Transport Proteins » Organic Anion Transporters » Organic Anion Transporters, ATP-Dependent » Multidrug Resistance-Associated Proteins
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Carrier Proteins » Membrane Transport Proteins » ATP-Binding Cassette Transporters » Multidrug Resistance-Associated Proteins
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Membrane Transport Proteins » ATP-Binding Cassette Transporters » Multidrug Resistance-Associated Proteins
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Membrane Transport Proteins » Ion Pumps » Anion Transport Proteins » Organic Anion Transporters » Organic Anion Transporters, ATP-Dependent » Multidrug Resistance-Associated Proteins
Description
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins. MeSH
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