Related MeSH Hierarchy (6)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Carrier Proteins » Membrane Transport Proteins » Ion Pumps » Anion Transport Proteins » Organic Anion Transporters » Organic Anion Transporters, ATP-Dependent » ATP Binding Cassette Transporter, Subfamily B
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Carrier Proteins » Membrane Transport Proteins » ATP-Binding Cassette Transporters » ATP Binding Cassette Transporter, Subfamily B
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Glycoproteins » Membrane Glycoproteins » ATP-Binding Cassette Transporters » ATP Binding Cassette Transporter, Subfamily B
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Membrane Glycoproteins » ATP-Binding Cassette Transporters » ATP Binding Cassette Transporter, Subfamily B
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Membrane Transport Proteins » ATP-Binding Cassette Transporters » ATP Binding Cassette Transporter, Subfamily B
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Membrane Proteins » Membrane Transport Proteins » Ion Pumps » Anion Transport Proteins » Organic Anion Transporters » Organic Anion Transporters, ATP-Dependent » ATP Binding Cassette Transporter, Subfamily B
Description
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology. MeSH
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