Diseases [C] » Infections [C01] » Central Nervous System Infections » Prion Diseases
Diseases [C] » Nervous System Diseases [C10] » Central Nervous System Diseases » Central Nervous System Infections » Prion Diseases
Diseases [C] » Nervous System Diseases [C10] » Neurodegenerative Diseases » Prion Diseases
Description
A group of genetic, infectious, or sporadic degenerative human and animal nervous system disorders associated with abnormal PRIONS. These diseases are characterized by conversion of the normal prion protein to an abnormal configuration via a post-translational process. In humans, these conditions generally feature DEMENTIA; ATAXIA; and a fatal outcome. Pathologic features include a spongiform encephalopathy without evidence of inflammation. The older literature occasionally refers to these as unconventional SLOW VIRUS DISEASES. (From Proc Natl Acad Sci USA 1998 Nov 10;95(23):13363-83) MeSH
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Subtype Terms (7)
Creutzfeldt-Jakob Syndrome
1 experimental drug
Wasting Disease, Chronic
14 drugs (3 approved, 11 experimental)
Other Experimental Indicated Drugs (1)
Organization Involved with Other Experimental Indications (1)
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UMLS Data
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