Related MeSH Hierarchy (4)
Chemicals and Drugs [D] » Enzymes and Coenzymes [D08] » Enzymes » Hydrolases » Peptide Hydrolases » Metalloproteases » Metalloendopeptidases » ADAM Proteins » ADAMTS Proteins » ADAMTS5 Protein
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Scleroproteins » Extracellular Matrix Proteins » ADAMTS Proteins » ADAMTS5 Protein
Chemicals and Drugs [D] » Carbohydrates [D09] » Glycoconjugates » Glycoproteins » ADAM Proteins » ADAMTS Proteins » ADAMTS5 Protein
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Glycoproteins » ADAM Proteins » ADAMTS Proteins » ADAMTS5 Protein
Description
An ADAMTS protease that contains two C-terminal thrombospondin (TS) motifs. It functions primarily as an aggrecanase, cleaving AGGRECAN in CARTILAGE, and may be involved in the destruction of aggrecan in ARTHRITIS. MeSH
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