Active Ingredient History
Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor. It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments. Veliparib may make whole brain radiation treatment work more effectively against brain metastases from NSCLC. It has been shown to potentiate the effects of many chemotherapeutics, and as such has been part of many combination clinical trials. Wikipedia
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Adenocarcinoma of Lung (Phase 1/Phase 2)
Adrenal Gland Neoplasms (Phase 1)
Astrocytoma (Phase 2)
Bile Duct Neoplasms (Phase 1)
Brain Diseases (Phase 1)
Brain Neoplasms (Phase 2)
BRCA1 Protein (Phase 2)
Breast Neoplasms (Phase 3)
Breast Neoplasms, Male (Phase 1)
Brenner Tumor (Phase 1)
Burkitt Lymphoma (Phase 1/Phase 2)
Carcinoma (Phase 1)
Carcinoma, Hepatocellular (Phase 2)
Carcinoma, Merkel Cell (Phase 1)
Carcinoma, Neuroendocrine (Phase 1/Phase 2)
Carcinoma, Non-Small-Cell Lung (Phase 3)
Carcinoma, Renal Cell (Phase 1)
Carcinoma, Small Cell (Phase 1/Phase 2)
Carcinoma, Transitional Cell (Phase 1)
Central Nervous System Diseases (Phase 1)
Choroid Plexus Neoplasms (Phase 1)
Colonic Neoplasms (Phase 1)
Colorectal Neoplasms (Phase 2)
Craniopharyngioma (Phase 1)
Diffuse Intrinsic Pontine Glioma (Phase 1)
DNA Mismatch Repair (Phase 1)
Endometrial Neoplasms (Phase 1)
Ependymoma (Phase 1)
Esophageal Neoplasms (Phase 1)
Fallopian Tube Neoplasms (Phase 2)
Gallbladder Neoplasms (Phase 1)
Glioblastoma (Phase 2/Phase 3)
Glioma (Phase 2)
Gliosarcoma (Phase 2/Phase 3)
Hamartoma (Phase 2)
Hemangiosarcoma (Phase 2)
Hodgkin Disease (Phase 1/Phase 2)
Intestinal Neoplasms (Phase 1/Phase 2)
Intraocular Lymphoma (Phase 1/Phase 2)
Leukemia (Phase 1)
Leukemia, Hairy Cell (Phase 1/Phase 2)
Leukemia, Lymphocytic, Chronic, B-Cell (Phase 1/Phase 2)
Leukemia-Lymphoma, Adult T-Cell (Phase 1/Phase 2)
Leukemia, Monocytic, Acute (Phase 1)
Leukemia, Myeloid, Acute (Phase 2)
Leukemia, Myelomonocytic, Acute (Phase 1)
Leukemia, Myelomonocytic, Chronic (Phase 2)
Liver Failure (Phase 1)
Liver Neoplasms (Phase 1)
Lung Neoplasms (Phase 1/Phase 2)
Lymphoma (Phase 1/Phase 2)
Lymphoma, B-Cell, Marginal Zone (Phase 1/Phase 2)
Lymphoma, Follicular (Phase 1/Phase 2)
Lymphoma, Large-Cell, Anaplastic (Phase 1/Phase 2)
Lymphoma, Large-Cell, Immunoblastic (Phase 1/Phase 2)
Lymphoma, Mantle-Cell (Phase 1/Phase 2)
Lymphoma, Non-Hodgkin (Phase 1/Phase 2)
Lymphoma, T-Cell (Phase 1/Phase 2)
Lymphomatoid Granulomatosis (Phase 1/Phase 2)
Medulloblastoma (Phase 1)
Melanoma (Phase 2)
Meningioma (Phase 1)
Multiple Endocrine Neoplasia Type 1 (Phase 1)
Multiple Endocrine Neoplasia Type 2a (Phase 1)
Multiple Endocrine Neoplasia Type 2b (Phase 1)
Multiple Myeloma (Phase 1/Phase 2)
Mutation (Phase 2)
Myelodysplastic Syndromes (Phase 1)
Myeloproliferative Disorders (Phase 2)
Neoplasm Metastasis (Phase 1)
Neoplasms (Phase 2)
Neoplasms, Germ Cell and Embryonal (Phase 1)
Nervous System Neoplasms (Phase 1)
Neuroectodermal Tumors (Phase 1)
Neuroectodermal Tumors, Primitive (Phase 1)
Neuroendocrine Tumors (Phase 1)
Oligodendroglioma (Phase 1)
Oropharyngeal Neoplasms (Phase 1/Phase 2)
Ovarian Diseases (Phase 1)
Ovarian Neoplasms (Phase 3)
Pancreatic Neoplasms (Phase 2)
Peritoneal Neoplasms (Phase 1)
Pheochromocytoma (Phase 1)
Polycythemia Vera (Phase 2)
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Phase 1/Phase 2)
Primary Myelofibrosis (Phase 2)
Prostatic Neoplasms (Phase 2)
Renal Insufficiency (Phase 1)
Rhabdoid Tumor (Phase 1)
Sezary Syndrome (Phase 1/Phase 2)
Skin Neoplasms (Phase 2)
Small Cell Lung Carcinoma (Phase 2)
Spinal Cord Neoplasms (Phase 1)
Squamous Cell Carcinoma of Head and Neck (Phase 1/Phase 2)
Stomach Neoplasms (Phase 1)
Testicular Neoplasms (Phase 2)
Thrombocythemia, Essential (Phase 2)
Thymoma (Phase 1)
Thyroid Neoplasms (Phase 1)
Triple Negative Breast Neoplasms (Phase 3)
Urinary Bladder Neoplasms (Phase 1)
Uterine Cervical Neoplasms (Phase 2)
Waldenstrom Macroglobulinemia (Phase 1/Phase 2)
Zollinger-Ellison Syndrome (Phase 1)
| Trial | Phase | Start Date | Organizations | Indications |
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