Related MeSH Hierarchy (5)
Diseases [C] » Neoplasms [C04] » Neoplasms by Site » Endocrine Gland Neoplasms » Multiple Endocrine Neoplasia » Multiple Endocrine Neoplasia Type 2a
Diseases [C] » Neoplasms [C04] » Neoplasms, Multiple Primary » Multiple Endocrine Neoplasia » Multiple Endocrine Neoplasia Type 2a
Diseases [C] » Neoplasms [C04] » Neoplastic Syndromes, Hereditary » Multiple Endocrine Neoplasia » Multiple Endocrine Neoplasia Type 2a
Diseases [C] » Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] » Genetic Diseases, Inborn » Neoplastic Syndromes, Hereditary » Multiple Endocrine Neoplasia » Multiple Endocrine Neoplasia Type 2a
Diseases [C] » Endocrine System Diseases [C19] » Endocrine Gland Neoplasms » Multiple Endocrine Neoplasia » Multiple Endocrine Neoplasia Type 2a
Description
A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease. MeSH
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Phase 2 Indicated Drugs (1)
Phase 1 Indicated Drugs (3)
Organization Involved with Phase 2 Indications (4)
Organization Involved with Phase 1 Indications (1)
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