Related MeSH Hierarchy (5)
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Fanconi Anemia Complementation Group Proteins » BRCA1 Protein
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Neoplasm Proteins » Tumor Suppressor Proteins » BRCA1 Protein
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Nuclear Proteins » BRCA1 Protein
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Phosphoproteins » BRCA1 Protein
Chemicals and Drugs [D] » Amino Acids, Peptides, and Proteins [D12] » Proteins » Transcription Factors » BRCA1 Protein
Description
The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91) MeSH
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